Searchable abstracts of presentations at key conferences in endocrinology
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17th European Congress of Endocrinology

Symposia

Androgens and disease progression in prostate cancer

ea0037s24.1 | Androgens and disease progression in prostate cancer | ECE2015

Leveraging circulating DNA studies to identify mechanisms of resistance to CYP17A1 inhibition

Attard Gerhardt

CYP17A1 inhibition with abiraterone is an effective treatment for castration-resistance prostate cancer (CRPC), with significant improvements in survival, radiological progression free survival, pain, skeletal related events and other secondary end-points. However, resistance invariably develops. Due to mineralocorticoid excess, abiraterone is administered with glucocorticoids. Next-generation sequencing of circulating plasma DNA from CRPC offers an opportunity to monitor tumo...