Endocrine Abstracts

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The relative risk associated with diabetes and obesity is significantly higher for different carcinomas including thyroid cancer. There is some evidence that insulin resistance and as a consequence hyperinsulinemia rather than hyperglycemia are responsible for the higher prevalence of cancer in diabetic and obese patients. In the thyroid insulin/IGF-depending signalling is part of the mitogenic pathways that regulate benign and malignant growth. In diabetics with hyperinsuline...

Epidemiological and preclinical studies propose that metformin, a first-line drug for type- 2 diabetes, exerts direct antitumoral activity. Although several clinical trials are currently ongoing, the molecular mechanisms of this effect are unknown. The AMP-activated kinase-dependent pathway, and the down-stream effectors (e.g. mTOR) are considered the main effectors. Several studies reported the involvement of, in metformin metabolic activity. Nevertheless, contrasting evidenc...