ea0035s25.3 | Gonadal hormones and obesity | ECE2014
Stener-Victorin Elisabet
The etiology of PCOS is not well understood, but genetic, epigenetic, and environmental factors have all been implicated in its development. Clinical evidence suggests that excessive secretion of sex steroids, in particular androgens, plays a role in the pathophysiology of PCOS. The main metabolic phenotype is hyperinsulinemia and insulin resistance (IR). These often precede the development of type 2 diabetes mellitus (T2DM) and occur independently of body weight, although obe...