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16th European Congress of Endocrinology

Symposia

Clinical outcome of medical intervention in Disorder of Sex Development (DSD)

ea0035s14.1 | Clinical outcome of medical intervention in Disorder of Sex Development (DSD) | ECE2014

dsd-LIFE: clinical European outcome study of disorders of sex development

Kohler Birgit , Arlt Wiebke , Bouvattier Claire , Chatelain Pierre , Grinten Hedi Claahsen van der , Cohen-Kettenis Peggy , Nordenstrom Anna , Pienkowski Catherine , Richter-Unruh Annette , Slowikowska-Hilczer Jolanta , Szarras-Capnik Maria , Reisch Nicole , Sultan Charles , Thyen Ute , Wiesemann Claudia

Disorders of sex development (DSD) include a conglomerate of rare conditions with discrepancy of the chromosomal, gonadal or phenotypic sex. Since the last 2 decades the genetic causes and the pathogenesis have been identified in many patients with DSD. Multidisciplinary clinical care as decision on the sex of rearing, genital surgery, hormone therapies and psychological support has a life-long impact on the affected persons. However, previous clinical outcome studies of DSD w...

ea0035s14.2 | Clinical outcome of medical intervention in Disorder of Sex Development (DSD) | ECE2014

Consequences of the preservation of underdeveloped testes in adulthood

Slowikowska-Hilczer Jolanta

Disorders of sex development (DSD) is the matter of controversy on what should be the methods of treatment. One of the main problem is preservation of underdeveloped gonads. The issue of concern are especially patients with gonadal dysgenesis and Y chromosome (with presence of potential testes) (GD) and patients with androgen insensitivity (46,XY and underdeveloped testes) (AIS). It was confirmed by many studies that the risk of germ cell neoplasia (GCN) is high in these gonad...

ea0035s14.3 | Clinical outcome of medical intervention in Disorder of Sex Development (DSD) | ECE2014

Developmental disruption of paracrine hormone regulation in the pathogenesis of germ cell neoplasms

Rajpert-De Meyts Ewa

The most common testicular germ cell tumours (TGCT), seminoma or non-seminoma, occur in young adults and are derived from an intratubular precursor, carcinoma in situ testis (CIS). CIS cells display characteristics of developmentally arrested fetal gonocytes which during puberty acquire some features of more mature germ cells. Developing germ cells are under control of their somatic niche (Sertoli- and peri-tubular cells) and androgen-producing Leydig cells. A develop...