ea0035gh1 | The Geoffrey Harris Prize Lecture | ECE2014
Grossman A
Pituitary adenomas are not rare, with a prevalence of around 1/1000 population. However, their pathogenesis has defied decades of careful study. Many groups including our own have shown a plethora of changes within these tumours, with silencing, often epigenetic, of many tumour suppressors, suggesting activation of a pro-proliferative programme. However, apart from the Milan groups Gsp mutation in somatotrophinomas no single mutational oncogenic event has been demonstrat...