Endocrine Abstracts

Objective: To investigate the effects of BPA on oxidative damage in terms of activity level of antioxidant enzymes in different regions of the rat brain.Background: The ever increasing uses of electronic gadgets are becoming a widespread source of bisphenol-A accumulation. As studies have been reported that low level BPA accumulation may produce neurological effects but still limited studies have re-examined for its adverse effects in terms of acute expo...

The present study was carried out to investigate the reproductive toxicity of butyl benzyl phthalate (BBzP) on semen characteristics, hormones levels (testosterone, LH and FSH), testicular lipid peroxidation and antioxidants enzymes and histological changes in testes in male rabbits for 12 weeks. The flaxseed lignan and its mammalian metabolites have been reported to exert protective effects against diet-related chronic diseases through a variety of mechanisms including phytoe...

Triclosan is one of endocrine-disrupting chemicals (EDCs) which are scattered with environment agents, such as toothpastes, deodorant and cleaning supplies. As a phytoestrogen, kaempferol is one of bioflavonoids, which has been found at variety of vegetables including broccoli, tea and tomato. Although kaempferol may have anti-cancer activity, its exact mechanism is under investigation in the induction of apoptosis and inhibition of cell proliferation or angiogenesis. In this ...

The distinct roles of estrogen receptors (ERs) related with androgen receptors (ARs) have been proposed in prostate cancer, while the involvement of transforming growth factor-β (TGF-β) has been reported in prostate cancer progression. We examined that TGF-β signaling pathway is associated with ER signaling in LNCaP prostate cancer cells, which express ERα and ERβ, and ARs. We determined whether the exposure to phthalate may induce the prostate cancer ...

In the present study, we determined whether two endocrine-disrupting chemicals (EDCs), triclosan (TCS) and octylphenol (OP), are able to alter the expression of two cell cycle regulators, cyclin D1 and p21, in both in vitro and in mouse breast cancer models. In addition, we determined whether the stimulatory effects of OP or TCS on breast cancer progression may be associated with an estrogen receptor (ER)-mediated signaling pathway. Altered expressions of cyclin D1 an...

Fenhexamid is one of antifungal agents used in agricultural applications, which are present at measurable amounts in fruits and vegetables. Fenhexamid has been reported to act as an anti-androgen in an androgen receptor reporter assay in engineered human breast cancer cells. Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor, which translocates into nucleus and dimerizes with aryl hydrocarbon receptor nuclear translocator (ARNT). Although function of AR...

Phthalates are mainly used as substances added to plastics for increase flexibility, durability and transparency. Although phthalates have been reported to act as endocrine-disrupting chemicals (EDCs) and appear to cause detrimental effects on human health, diverse cancers and diseases, exact effect(s) and underlying mechanism(s) remain uncovered. The estrogenic activity of EDCs is partially associated with ability to stimulate cell viability in estrogen-dependent cancers expr...

Bisphenol A (BPA) is a widespread endocrine disrupting chemical strongly suspected to have adverse health effects. Numerous tissues and cells are affected by BPA, and we showed recently that BPA targets include ameloblasts and enamel. We therefore investigated the effects of BPA on ameloblasts and the possible involvement of the estrogen signaling pathway. Rats were exposed daily to low-dose BPA from the conception to 30 days after birth (30 D). Seventy-five percent of 30 D ra...

Aim to study the particularities changes of organometric parameters of rat’s adrenal glands after 60-day administration of sodium benzoate and justify possible correction of identified changes by application of mexidol.The study was conducted on 90 mature male rats with an initial weight of 200–210 g, which were divided into three groups: 1st group – control animals, 2nd group – rats that within 60 days daily intragastrically injected...

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age, that lead to infertility, type 2 diabetes and coronary heart disease.Bisphenol A (BPA) is one of the most abundant chemicals produced worldwide and is used as a plasticizer in daily life. Nowadays it is also well know that it can interact with estrogen receptors, androgen receptors and peroxisome proliferator-activated receptors γ (PPARγ). Therefore...

Introduction: Testicular germ cell tumours are the most frequent cancer of young men. Epidemiological and clinical data have suggested that fetal or perinatal exposure to environmental endocrine disruptors (EEDs) with estrogenic effects, could participate to testicular germ cell carcinogenesis. However, EEDs (like bisphenol A (BPA) are often weak ligands for classical nuclear estrogen receptors.Using a human seminoma cell line (JKT-1), devoid of ERα...

Introduction: Phthalates are suspected to influence thyroid function in epidemiologic and experimental animal studies. The aim of the study was to investigate the ability of primary human thyroid cell cultures to metabolise phthalates and a possible concentration-dependent response of phthalates on thyroglobulin (Tg) secretion.Methods: Human thyrocytes obtained from thyroidectomies were cultured to confluent monolayers. These were exposed to DEHP in conc...