Endocrine Abstracts

Context: Adipose tissue distribution is closely related to metabolic disease risk. GH reduces visceral and total body adipose tissue mass, while inducing whole body insulin resistance.Objective: To assess the role of visceral adipose tissue and derived adipokines for the systemic insulin resistance and lipid metabolism, before and after treatment in acromegaly.Patients: Sixty-six adult patients with active acromegaly diagnosed betw...

Introducing: Acromegaly is characterized by excessive GH and IGF1 secretion. Recent date suggests that soluble α-Klotho is also elevated in patients with acromegaly.Objective: The aim of this study was to assess the serum levels of soluble α-Klotho in patients in relation with the activity of disease and to compare with control group (CG). We also examine the relationship between excess GH, IGF1 and serum levels of soluble α-Klotho in pati...

Aim: Cardiac rhythm abnormalities have been documented in acromegalic patients. Our aim is to evaluate atrial electromechanical delay (EMD) with tissue doppler imaging (TDI) in patients with acromegaly.Material and methods: Fourty patients with acromegaly (13 patients with remission disease and 27 patients with active disease; 22 women and 18 men; mean aged 46.1±10.3 years), and 37 age- and sex-matched healthy controls were enrolled in the study. At...

Background: A proof-of-concept study (LINC 1) demonstrated that after 10 weeks, LCI699 normalized UFC in 11/12 patients with Cushing’s disease. This interim analysis of the first eight patients enrolled into a longer-term study (LINC 2) further evaluates LCI699 in Cushing’s disease; the full analysis on all 19 enrolled patients is expected in time for the congress.Methods: There were two study groups. Previous LINC 1 participants (follow-up coh...

Introduction: A wide variety in hydrocortisone substitution dose-regimens are considered physiological for patients with secondary adrenal insufficiency. However, it is likely that cognition is negatively influenced by higher cortisol exposure to the brain. So far, no studies have been performed to assess the effects of treatment regimens administered for a substantial period of time with a low physiological hydrocortisone dose in comparison to a high physiological hydrocortis...