Endocrine Abstracts

In rats, we have previously demonstrated that consumption of low-carbohydrate/high-fat diets (LC–HFD) led to significant reductions in circulating IGF1. We further observed that rats fed an extreme, ketogenic, but comparably low protein LC–HFD (LC–HF-2) showed loss of bodyweight, which was mainly due to loss of lean body mass (LBM). Consumption of a moderate protein LC–HF diet (LC–HF-1) did not affect LBM acquisition compared to controls. We now invest...

To determine the effects of zilpaterol hydrochloride (Zh) on carcass composition and growth performance of Lory growing lambs, 21 lambs with age 7–8 month and body weight 37.5±1.2 kg was assigned in three groups with 7 replications: group one as control, group 2 received Zh every two days, and group 3 received Zh every day. Lambs orally received 0.2 mg/kg of live body weight mixed with their daily diets during finishing period (as zilpaterol hydrochloride, Zilmax, In...

Purpose: To study comparative influence of replacement GH therapy on a level of secretion of GH, IGF1 and IGFBP-3 in girls with endocrine and hereditary stunting.Materials and methods: Forty-six girls aged 5.5 to 17 were examined. Of them somatotropic insufficiency (STI) was found in 13 girls, multiple deficiency of adenohypophyseal hormones (MDAH) in 11, idiopathic nanism (IN) in 12, Turner syndrome (TS) in 10 girls. Patients received subcutaneous injec...

Introduction: Previous data from our group suggested a role for the GH/IGF1 axis in the pathophysiology of osteoporosis in thalassemia (Clin Endocrinol 69:202, 2008). The present study was aimed at evaluating the relationships between circulating IGFs and bone metabolism and density in a very large series of adult thalassemic patients.Study design: One hundred and thirty-nine patients affected by thalassemia major (mean age 32.3±7.87 years) underwen...

Background: The exon-3 deletion in the growth hormone receptor gene (d3 GHR) leads to an enhanced GH signal transduction. Acromegalic patients with the d3 GHR genotype could be expected to have more marked clinical or biochemical manifestations for a given GH level than those with the wild (fl) type GHR. We studied acromegalic patients for clinical and/or biochemical disease recurrence after surgery in relation to GHR genotype status to assess whether d3 GHR influences the rel...

Background: Insulin-like growth factor 1 (IGF1) plays a central role in metabolism and growth regulation. High IGF1 levels are associated with an increased risk of cancer, low IGF1 levels with increased risk for cardiovascular disease. We hypothesized that the relationship between circulating total IGF1 levels and mortality is U-shaped.Methods: We performed a systematic review searching PubMed, EMBASE, Web of Science, Cochrane Library (1985 to September ...

Glycoprotein hormones are used clinically in the treatment of many diseases. One major issue regarding the clinical use of many peptides is their short half-life due to the rapid clearance from the circulation. The major strategies for overcoming this problem by pharmaceutical companies are based on chemical techniques. To overcome this problem, we used genetic engineering techniques that have been found successful for designing long acting hormones. Overlapping PCR techniques...