Endocrine Abstracts

Patients type 2 diabetes mellitus and MI need multimodality treatment including, besides of drug therapy, non-drug approaches. Repeated Treadmil exercise test is open second window of preconditioning. Ischemic preconditioning limits infarct size in the heart, increase level of physical activity.Study aim: To study the effect of early started repeated Treadmil exercise tests in patients with type 2 diabetes mellitus and MI.Design: O...

Glucagon-like peptide-1 (GLP-1) is an incretin hormone playing an important role in glucose-dependent insulin secretion and β-cell growth. However, GLP-1 is rapidly degraded by dipeptidyl peptidase IV (DPP-IV) in vivo. Many attempts have been made to develop long-acting GLP-1 analogs with chemical modification, amino acid substitution, and fusion protein technology. We previously showed that the N-terminal Ala- or Gly-extended GLP-1 and human immunoglobulin ...

Introduction: Telehealth systems have become an alternative method to control chronic illnesses like diabetes. The aim of this study was to evaluate a telehealth system in patients with type 1 diabetes who have an optimized treatment with an insulin pump and real-time continuous glucose monitoring system.Research design and methods: Prospective, 1-year study of 15 patients with a continuous insulin infusion system and a real time glucose sensor. Three me...

Objective: Our objective in this study was to identify the type of clinical care received by young type 1 diabetic patients who have made the transition from paediatric to adult care, and to assess the metabolic status of the patients. The research aimed to develop a sustainable and coordinated approach to facilitating the transition between diabetes services for adolescents and reveal from the perspective of the adolescents living with type 1 diabetes their experiences surrou...

Objective: Calculation of accurate insulin boluses is one of the major problems related to intensive insulin regimens. A bolus calculator (BC) incorporated into the insulin pump estimates the dose of insulin to be administered at the meal and makes calculation easier and more precise.The aim of the present study was to assess the efficacy of a BC on glycaemic control of patients with DM1 on CSII.Material and methods: We enrolled 20...

Introduction: Several studies have shown that treatment with insulin pump is an effective therapy for selected type 1 diabetes. Nevertheless, most of them analyse results in short period of time. The objective of this study is to evaluate long term effects on quality of life (DQOL) and metabolic control of CSII.Material and methods: We did a longitudinal study of type 1 diabetic patients previously treated with multiple daily insulin (MDI) therapy who in...

Introduction: Simultaneous pancreas kidney transplant (SPK) is a prime line treatment option in patients with type 1 diabetes and chronic kidney failure. The glucose control during perioperatory period can be a prognostic factor for transplant. Actually, the utility of the continuous glucose monitoring is not well defined. Our objective was to study the utility of a continuous glucose monitoring system during the simultaneous pancreas kidney transplant.M...

In Europe more than 50 million adults are diabetic. Of these, 90–95% have type 2 diabetes (T2D). It is also recognized that an even larger population is insulin resistant and it is thought that treatment at this early phase of the metabolic syndrome may prevent the occurrence of overt diabetes and associated pathologies. We are in the process of developing unacylated ghrelin (UAG) analogues as therapeutics for T2D. Towards this goal, we have used a mouse protocol in which...

Possible involvement of creatine in the regulation of glycaemia in diabetic patients has been implicated.The aim of this study was to investigate the short-term effect of creatine on the glycaemic profile during standard meal in comparison to the oral sulfonylurea hypoglycaemic agent glibenclamide, in type II diabetic patients.In a 14-day simmetrically randomized crossover trial, recently detected type II diabetic patients received...

Background: Increased liver and cardiac fat are common in patients with type 2 diabetes mellitus (T2DM) and associated with increased risc for liver fibrosis and cardiovascular events. The effect of a DPP-4 inhibitor vildagliptin on the fat content of the liver and heart has not been evaluated.Methods: A total of 40 patients, 20 males and 20 females, treated at our diabetes metabolic unit of the Medical University of Vienna with gliptins underwent magnet...

Introduction: The efficacy of self monitoring of blood glucose (SBMG) on glycaemic control in non-insulin-treated (NIT) type-2-diabetes-mellitus (T2DM) is still controversial. In this paper we evaluated the influence of SMBG on glycaemic control in patients with T2DM with poor glycaemic control treated with oral antidiabetic agents.Methods: Thirty NIT-T2DM patients with poor glycaemic control and HbA1c>7% under treatment with oral hypoglycaemic agent...

Objective: The aim of the present study was to determine whether insulin resistance is important in well controlled, uncomplicated patients with type 1 diabetes on long term CSII, compared to matched healthy controls.Research design and methods: We studied 8 patients (4 men and 4 women) with type 1 diabetes on stable continuous subcutaneous insulin pump therapy and 8 healthy controls, matched for age, gender and BMI. Insulin sensitivity was measured by h...

Background: Guidelines for management of diabetes mellitus (DM) provide standardization of care and treatment. National clinical practice guidelines on DM have been developed in 2006 by The Society of Endocrinology and Metabolism of Turkey and reviewed annually.Methods: One hundred and eighty physicians evaluated previous 12 months’ medical records of their type 2 DM patients with special emphasis on whether the patients were followed consistently w...

Introduction: Sexual dysfunction is more prevalent in postmenopausal women with diabetes mellitus.Objective: The aim of the study was to prospectively evaluate the effects of oral estradiol+drospirenone on sexual function in postmenopausal women with type 2 diabetes mellitus.Methods: The study included 86 postmenopausal women with type 2 diabetes mellitus who were randomized into two groups: 44 women received oral 17β-estradio...

Background: Sitagliptin, unlike the some major antihyperglycaemic drugs, is not associated with weight gain and has neutral effects on body weight. It is unclear whether sitagliptin treatment alters serum ghrelin levels in people with type 2 diabetes. The aim of the present study was to assess the effect of sitagliptin on serum ghrelin levels in patients with type 2 diabetes mellitus.Methods: Forty-four type 2 diabetic subjects were randomly assigned to ...

Objectives: The aim of the audit was to determine how our current clinical practice differs from that of the national standard set out in the UK by NICE guidance CG87 in regards to the use of exenatide.Material and methods: We measured weight and HbA1c at baseline and then again at 6 months from the date exenatide was started. The UK NICE guidelines recommends exenatide should only be considered in patients with a BMI≥35.0 kg/m2 with a H...

Background: Asian has higher prevalence of diabetic nephropathy and end-stage renal disease as compared to Caucasian. No study to date has evaluated whether multifactorial intervention was associated with remission of microalbuminuria in type 2 diabetic Asian population. We evaluated the effect of tightly controlling multiple factors on the remission of diabetic nephropathy in type 2 diabetic Chinese with microalbuminuria.Materials and methods: A total o...

The pathogenesis of type 2 diabetes is explained by increment of insulin resistance and dysfunction of insulin secretion. If improvement of insulin resistance is not adequate in the early stage of diabetes especially in this country with more severe basal insulin secretion defect from the very beginning, diabetes rapidly progress to more aggressive stage with relative insulin deficiency. The most proper method of improving insulin resistance by prescription is metformin from t...

Introduction: By using insulin analogue, it is expected to improve glycemic regulation in poorly controlled type 2 diabetes (t2DM). The aim of the study was to examine the quality of glycemic control and quality of life (QoL) of patients managed with insulin analogues, previously treated with human insulin.Materials and methods: The pilot study included 30 t2DM outpatients, divided into two groups (15 subjects) – the first group was treated with hum...

Aim: To assess the effectiveness, safety and tolerability of Exenatide twice daily treatment of type 2 diabetes and obesity.Material and methods: Data analysis of obese type 2 diabetic patients initiated on Exenatide therapy in our Endocrine clinics who complete 1 year of treatment.Results: We included 42 patients, 30 women (71.4%) and 12 men (28.6%), mean (±S.D.) age 57±10 and 9±7 years diabetes evolu...

Purpose of the study: Research dynamic of parameters of mineral metabolism, during 12 months therapy with Strontium ranelate (in dose – 2 g/day) at women with postmenopausal osteoporosis and diabetes type 2 (D2).Materials and methods: Forty-two women (age 65.9±3.2 years) in postmenopausal period with verified DM2 (DM2 longer from 1 to 12 years, all patients have standard on per oral therapy with ant diabetes drag – gliclazide, metformin or...

Introduction: Studies show that a change in lifestyle can prevent or delay progression to diabetes in those with glucose intolerance. This study aimed to survey the effects of lifestyle changes on incidents of type II diabetes in Tehran adult population.Materials and methods: This was a community based interventional study. Non-diabetic participants of Tehran Lipid and Glucose Study aged ≥20 years (6437 in control group and 2931 in intervention gro...

Patients with type 2 diabetes have an increased risk of premature coronary heart disease (CHD). One of the underlying reasons for this increased risk is atherogenic dyslipidemia. Current management strategies focus on the initial use of statin or fibrate therapy (the latter approach indicated in patients with pronounced hypertriglyceridemia).American Diabetes Association recognizes serum triglycerides as a surrogate for atherogenic triglyceride-rich lipo...

Background and aims: Incretin mimetics are a new class of pharmacological agents with antihyperglycemic actions that mimic the actions of incretin hormones originating in the gut, such as glucagon-like peptide (GLP)-1. The thyroid gland exhibit a strong GLP-1 receptor expression in rodents but only low receptor levels in humans. GLP-1 receptors activation stimulates calcitonin secretion and promotes the development of C cell hyperplasia and medullary thyroid cancer in rodents....

Introduction: Clinical trials have show n that improved glycemic control reduces the incidence and progression of diabetes complications. One of the most important steps in diabetes treatment is to educate patients how to manage self monitorining blood glucose (SBGM) and adjust their life habits with their diabetes. A new diabetes management concept of structured testing is supported by Accu -Chek 360 View.Objectives: Assess the impact of structured test...

Purpose of work: Research influence of insulin therapy in the form of combine therapy with analogue of prolonged insulin – glargin and per oral anti diabetes treatment with (glibenclamide) on dynamics of risk of development of coronary (CHD) heart disease and death rate from cardiovascular disease (CVD) at diabetes mellitus type 2 (DM 2).Materials and methods: During the study was researched dynamic of risk of development CHD and death rate from CVD...