ea0026pl2 | Making sense with thyroid hormone | ECE2011
Forrest Douglas
, Cordas Emily
, Fu Yulong
, Liu Hong
, Lu Ailing
, Ma Michelle
, Ng Lily
, Peeters Robin
, Sharlin David
Thyroid hormone has long been known as a key developmental factor in human and model species. Insufficient thyroid hormone during development can impair the growth and maturation of diverse tissue and organ systems. One of the most serious risks associated with congenital hypothyroidism is defective brain maturation and mental retardation. However, in recent years, targeted mutagenesis of the thyroid hormone receptor genes in model species has expanded our understanding of the...