Endocrine Abstracts

Introduction: The ghrelin gene products ghrelin and obestatin (Ob) protect mice from STZ-induced β-cell death, inflammation and STZ-induced diabetes. A possible event is ghrelin/Ob-induced regeneration of damaged β-cell population through the recruitment of pancreatic progenitor cells (PPC). We hypothesized that Ob affects proliferation and endocrine commitment of PPC within the islets of Langerhans.Methods: Islets of Langerhans were isolated f...

Background: Recently, we showed that rats on a free-choice high-fat high-sugar (fcHFHS) diet became rapidly obese and developed glucose intolerance within a week. Interestingly, rats on a free-choice high-fat diet (fcHF), although equally obese and hyperphagic as rats on a fcHFHS diet, did not develop glucose intolerance. Glucose tolerance was also unaffected in rats on a free-choice high-sugar diet, although they consumed more liquid sugar than rats on a fcHFHS diet. Hence, t...

Objective: Metformin is one of the most widely used drugs in primary therapy for the treatment of type 2 diabetes (T2D). Despite its overall efficiency in T2D treatment metformin shows significant proportion of patients suffering from number of side effects. So far number of polymorphisms mainly in genes coding for various metformin transporter proteins have been described in association with metformin efficiency. However, no information exists on influence of genetic variatio...

Introduction: Human leukocyte antigen-G (HLA-G) is a non-classical HLA-class Ib molecule with multiple immunoregulatory properties. Its main role is the maintenance of tolerance between maternal immune system and semiallogenic fetus. The expression of HLA-G antigen has been reported in several cancers and seems to play an important role in the escape of tumour cells from immune surveillance. A 14 bp insertion/deletion polymorphism in exon 8 of the 3′ untranslated region ...

Objective: The objective of this clinical trial is to compare four strategies of management of postoperative radioiodine ablation in a 2×2 factorial design, each strategy combining a method of TSH stimulation and an activity of 131I. The primary endpoint is the rate of thyroid ablation.Patients and methods: This multicentric, randomized, controlled, phase III trial involved 24 French centers, and compared 4 strategies for postoperative radioiodine a...

Objective: To evaluate prospectively the relationship between Yersinia Enterocolitica (YE) infection and the development of overt autoimmune hypo- or hyperthyroidism (study A) and the de novo occurrence of thyroid antibodies (study B).Subjects and methods: Prospective cohort study of 790 euthyroid women who were 1st or 2nd degree relatives of AITD patients. Follow-up was 5 years, with annual assessments.Study A. Nested case&...