Endocrine Abstracts

Increased plasma triglyceride (TG) concentration is an important risk factor for cardiovascular disease. Regular aerobic exercise is associated with lower plasma TG concentrations and lower cardiovascular risk. The cardioprotective effect of endurance-type physical activity is therefore likely, to some extent at least, linked to the hypotriglyceridemic effect of aerobic exercise. It has long been recognized that the TG-lowering effect of exercise manifests in response to a sin...

Chronic low-grade systemic inflammation is a feature of chronic diseases such as cardiovascular disease and type 2 diabetes. Regular exercise offers protection against all-cause mortality, primarily by protection against atherosclerosis and insulin resistance and there is evidence that physical training is effective as a treatment in patients with chronic heart diseases and type 2 diabetes. Regular exercise induces anti-inflammatory actions. During exercise, IL-6 (interleukin-...

Modern lifestyle diminished significantly the need of everyday exercise, which is probably one of the major factors leading to the development of several metabolic diseases including type 2 diabetes, hypertension and atherosclerosis with its deadly consequences. Epidemiological studies proved that higher levels of cardio-respiratory fitness are associated with lower mortality irrespective of fat stores. Physical activity reduces all-cause, cardiovascular as well as cancer asso...

Osteocytes are the most abundant cell type in bone; however, they remain the least characterised of these. Several theories have been proposed regarding their function, including osteolysis, sensing the strains produced in response to mechanical loading of bones and producing signals that affect the function of osteoblasts and osteoclasts as well as the expression of molecules that directly affect the turnover process. This review also discusses the role of osteocyte apoptosis...