Searchable abstracts of presentations at key conferences in endocrinology
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10th European Congress of Endocrinology

Symposia

Stem cell and regeneration

ea0016s25.1 | Stem cell and regeneration | ECE2008

Generation and patterning of patient-specific pluripotent stem cells

Lengerke Claudia , Daley George

Cellular transplantation has enormous potential for treating a variety of degenerative or malignant conditions. While adult stem cells display limitations in expansion capacity and developmental potential, embryonic stem (ES) cells are an inexhaustable source of tissues for research and therapy. During the last decade, human ES cells have been isolated, and differentiated to several tissue-specific progenitors. In vitro differentiating ES cells recapitulate early steps ...

ea0016s25.2 | Stem cell and regeneration | ECE2008

Stem cells in the gonads: novel options for fertility preservation?

Schlatt Stefan

Male and female germline development during sexual differentiation differs significantly. While in the testicular microenvironment primordial germ cells differentiate into a stem cell, the spermatogonium, the female pathway leads to the establishment of a limited pool of oocytes arrested in prophase of meiosis. Recently, exciting research has improved the understanding of pathways involved in germ cell differentiation and maintenance of pluripotency. In vitro and in ...

ea0016s25.3 | Stem cell and regeneration | ECE2008

The cell biology of neural stem and progenitor cells

Huttner Wieland B

Our group studies the cell biological mechanisms of neurogenesis in the context of mammalian brain evolution, specifically the proliferation versus differentiation of neuroepithelial (NE) cells and their progeny. In the course of neurogenesis, mouse NE cells down-regulate a number of epithelial features. Expression of the anti-proliferative gene Tis21 can be used as a tool to distinguish between proliferating and neuron-generating NE cells. Time-lapse microscopy of neuron-gene...

ea0016s25.4 | Stem cell and regeneration | ECE2008

Beta cell progenitor niche(s) and derivation of such cells from human ES cells

Semb Henrik

The pancreas originates from the definitive endoderm-derived gut epithelium. Much has been learnt about the specification of the gut endoderm into pancreatic progenitors and their progenies, the endocrine (islets of Langerhans) and exocrine cells, by various transcription factors. However, less is known about the extracellular cues that regulate the expression of such transcription factors. Human ES cells have emerged as a potential tool for studying human pancreas development...