Searchable abstracts of presentations at key conferences in endocrinology
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196th Meeting of the Society for Endocrinology and Society for Endocrinology joint Endocrinology and Diabetes Day

Symposia

Hormone measurements: past, present and future

ea0010s17 | Hormone measurements: past, present and future | SFE2005

Ligand assay - origins, present state of the art and ultimate future

Ekins R

“Ligand” (or “binding”) assays – a class of methods of which for many years immunoassay long constituted the most widely used example – were first applied (in the late 50 s/early 60 s) to measurements of hormone concentrations in body fluids, but were later extended to the assay of other substances present in samples at low concentrations. This presentation reviews the main developments in this field, including those presently occurring (which...

ea0010s18 | Hormone measurements: past, present and future | SFE2005

Steroid profiling

Taylor N

Techniques of analysis of urinary steroid metabolites evolved rapidly in the 1960 s from paper via thin layer and gas-liquid chromatography (GC) to GC-mass spectrometry. Formation of trimethylsilyl derivatives was a critical development for GC. This enabled all the major analytes to be identified and quantified in one run and the term ‘steroid profile’ for this first emerged in 1968. The use of capillary columns in place of packed columns, pioneered in the UK in th...

ea0010s19 | Hormone measurements: past, present and future | SFE2005

Detecting growth hormone abuse in athletes

Strasburger C , Bidlingmaier M , Wu Z

Performance enhancing substances enjoy considerable popularity among athletes, particularly if deemed undetectable. Doping with growth hormone has been considered undetectable until recently. Two strategies have been pursued to detect GH doping: Pharmacological endpoints and GH isoform composition.For the former approach the consortium GH 2000/2004 has identified markers of GH action and found a combination of parameters from the IGF-system and collagen ...

ea0010s20 | Hormone measurements: past, present and future | SFE2005

Metabolomics: its value in cancer research

Wheatley D

Metabolomics purports to give us a cross-section of the small molecular weight components in cells, tissues, organ, body fluids or the whole body at any moment in time, such that the constellation of molecules and their relative proportions can provide us with information about the functional state (or the dysfunctional state) at that time. From reading such a profile, information might be gleaned that indicates some activity state that is meaningful in the prese...