ea0006s10 | Gaseous signalling | SFE2003
Ratcliffe P
Hypoxia inducible factor (HIF) is an a/b heterodimeric transcriptional complex that mediates a broad range of cellular and systemic responses to hypoxia. Transcriptional targets include genes involved in angiogenesis, erythropoiesis, catecholamine metabolism, matrix metabolism, energy metabolism and cell survival decisions. Whilst HIF-b subunits are constitutive nuclear proteins, both the abundance and activity of HIF-a subunits are strongly inducible by hypoxia, leading to fo...