Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 6 | SFE2003 | Next issue

194th Meeting of the Society for Endocrinology and Society for Endocrinology joint with Diabetes UK Endocrinology and Diabetes Day

ea0006p52 | Bone | SFE2003

sRANK-L AND OPG ARE INCREASED IN SOME OSTEOPOROTIC PATIENTS

Jabbar S , Weston C , Drury J , Varey J

The importance of the sRANK-L / RANK / Osteoprotegerin (OPG) system in osteoclast function has clearly been demonstrated in the rat. Activating and inactivating mutations lead to severe disturbances of bone remodelling.Since this early animal work, there have been several studies designed to assess the importance of sRANK-L / RANK / OPG in diseases of the human skeleton. sRANK-L and OPG are measurable in blood.This cross-sectional ...

ea0006p53 | Bone | SFE2003

VITAMIN D INSUFFICIENCY AND PLASMA LEVELS OF sRANK-L and OPG IN OSTEOPOROTIC WOMEN

Jabbar S , Drury J , Varey J

The TNF members sRANK-L & Osteoprotegerin (OPG) are essential paracrine mediators of osteoclast function in vitro. The aim of this study was to establish the relationship between 25-hydroxyvitamin D and sRANK-L and OPG in plasma of osteoporotic patients.The study population consisted of 185 osteoporotic women (mean age 62.4 years), with bone mineral density (BMD) more than 2.5 SD below the young adult value, and 185 age-matched controls, with normal ...

ea0006p54 | Bone | SFE2003

sRANK-L AND OPG CORRELATE WITH BONE MINERAL DENSITY IN OSTEOPOROSIS

Jabbar S , Drury J , Varey J

The Osteoprotegerin (OPG) RANK and RANK-L system is a novel paracrine system that forms part of the mechanism of bone turnover. The aim of this study was to explore if the OPG/ RANK-L system, detectable in blood, is related to bone mineral density.The study population consisted of 185 osteoporotic women (mean age 62.4 years), with bone mineral density (BMD) more than 2.5 SD below the young adult value, and 185 age-matched controls, with normal bone miner...