Searchable abstracts of presentations at key conferences in endocrinology
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194th Meeting of the Society for Endocrinology and Society for Endocrinology joint with Diabetes UK Endocrinology and Diabetes Day

Poster Presentations (1)

Diabetes, metabolism and cardiovascular

ea0006dp1 | Diabetes, metabolism and cardiovascular | SFE2003

Silent myocardial ischemia in patients with type II diabetes mellitus without the clinical manifestations of ischemic heart disease in Turkish population

Ugur-Altun B , Altun A , Guldiken S , Kara M , Tugrul A

Accelerated coronary and peripheral vascular atherosclerosis is one of the most common and chronic complications of diabetes mellitus. A relatively recently analysed aspect of coronary artery disease in this condition is its silent nature. We studied silent myocardial ischaemia (SMI) in unselected consecutive middle aged asymptomatic patients with type II diabetes by treadmill exercise test.Ninety four asymptomatic type II diabetics between the ages 36 a...

ea0006dp2 | Diabetes, metabolism and cardiovascular | SFE2003

Diurnal variation in insulin sensitivity

Murray J , Darko D , Bermudez C , Anyaoku V , Robinson S

Objectives: The extent and mechanisms of the diurnal variation in insulin sensitivity are poorly described. This study set out to assess the relative contributions of diurnal rhythm and length of fast to insulin sensitivity in normal healthy human subjects.Methods: Nine healthy women (age 25.3±1.2 years, BMI 22.4±0.8 Kg/m2) ate a standardised meal before each of the four fasts, two ten-hour fasts ending at 0900 and 1700 and two thirteen-hou...

ea0006dp3 | Diabetes, metabolism and cardiovascular | SFE2003

Pancreatic islet protective effect of vanadium in streptozotocin-induced diabetic rats, histological, immunohistochemical and ultrastructural study

Ahmadi S , Karimian S , Sotoudeh M , Bahadori M

Objective: Vanadium salts have been suggested as a possible therapeutic agent for treating diabetes mellitus in the experimental models of the disease. This study was done to show the correlation between amelioration of diabetic signs and preservation of pancreatic islets in vanadyl sulphate treated streptozotocin - induced diabetic rats.Methods: Diabetes was induced in male Wistar rats by intravenous injection of 40 milligram per kilogram streptozotocin...

ea0006dp4 | Diabetes, metabolism and cardiovascular | SFE2003

AMBULATORY BLOOD GLUCOSE MEASUREMENT IN A NON-PATIENT GROUP OF WOMEN REPORTING SYMPTOMS OF REACTIVE HYPOGLYCAEMIA

Simpson E , Holdsworth M , Macdonald I

Reactive Hypoglycaemia (RH) is a controversial condition that has been popularised in the media and lay literature. A recent survey of randomly selected women in Nottinghamshire revealed that 37.8% experience symptoms that they attribute to a 'low blood sugar', with over 18% experiencing symptoms more than once a week (1). The aim of this study was to investigate whether a non-patient group who report symptoms synonymous with RH have concomitant hypoglycaemia.<p...

ea0006dp5 | Diabetes, metabolism and cardiovascular | SFE2003

AN AUDIT OF THE MANAGEMENT OF DIFFERENTIATED THYROID CANCER IN A SPECIALIST CLINIC IN A LARGE DISTRICT HOSPITAL

Mukhtar M , Williams L , Elsheikh M

Objective: Despite being the most common endocrine malignancy, the management of thyroid cancer in the UK remains sub-optimal, with reduced survival rates compared with Western Europe. The British Thyroid association published national guidelines in March 2002 to help standardize and improve the management and survival of thyroid cancer in the UK. We have audited the management of thyroid cancer in a large district hospital comparing the results to the standards set by the Bri...

ea0006dp6 | Diabetes, metabolism and cardiovascular | SFE2003

An unusual case of phaeochromocytoma

Clarke M , Choo-Kang A , Cooper M , Kumar S , Dodson P , Rahim A

A 62 year old woman presented in May 2001 with a one year history of palpitations. A 24 hour tape showed a short run of supra ventricular tachycardia only.In December 2001 she was admitted with palpitations, presyncope and a labile blood pressure. Systolic pressures of 150-186mmHg and diastolic pressures of 95-112mmHg were recorded. 24 hour urine collection for catecholamines revealed normal adrenaline levels but elevated noradrenaline at 5265 nanomols p...

ea0006dp7 | Diabetes, metabolism and cardiovascular | SFE2003

MODULATION OF NICOTINE MEDIATED RESPONSES IN HUMAN GINGIVAL FIBROBLASTS BY PLATELET DERIVED GROWTH FACTOR (PDGF) AND THE ALKALINE PHOSPHATASE INHIBITOR LEVAMISOLE

Soory M , Suchak A

The anabolic role of androgens in growth and regeneration, has similar implications in periodontal tissues. Studies suggest that androgens and growth factors could affect activity of the enzyme alkaline phosphatase, being closely linked to anabolic effects on tissues matrices. Nicotine has detrimental effects on healing. One of the mechanisms involved is impairment of alkaline phosphatase activity. The aim of this investigation is to study the response of nicotine to platelet ...

ea0006dp8 | Diabetes, metabolism and cardiovascular | SFE2003

TRANSFORMING GROWTH FACTOR BETA (TGF) and INSULIN LIKE GROWTH FACTOR (IGF) MEDIATED RESPONSES, TO SERIAL CONCENTRATIONS OF NICOTINE, USING ANDROGEN BIOMARKERS IN HUMAN GINGIVAL FIBROBLASTS

Soory M , Suchak A

Physiologically active androgens and growth factors contribute to healing responses by a variety of mechanisms, including stimulation of enzymes associated with matrix turnover. Some of these effects may be partially negated by nicotine. Both androgens and growth factors are able to compensate for oxidative effects induced by nicotine, being a significant deterrent to wound healing. The aim of this investigation is to establish the metabolic yields of androgen biomarkers in re...

ea0006dp9 | Diabetes, metabolism and cardiovascular | SFE2003

Treatment of metabolic syndrome with topiramate. An open study

Messina G , Proietti R , Faroni J

Topiramate is an antiepileptic drug, with anoressant effect, known to positively modulate GABA receptors. There are some published data concerning the use of topiramate in mood disorders (expecially BED), while there are not know data on its use in obese patients without BED. This is a preliminary study to explane the effectiveness and tolerability of topiramate in non-Binge Eating Disorder (BED) obese patients with metabolic syndrome. We described the effects of topiramate, w...

ea0006dp10 | Diabetes, metabolism and cardiovascular | SFE2003

Confirmation of altered hypoglycaemia awareness by structured questionnaire and continuous ambulatory glucose profiles in those with Type 1 diabetes mellitus complicated by severe hypoglycaemia

Thomas R , Leech N , Shaw J

Objectives: To define clinical and metabolic factors associated with severe hypoglycaemia (SH) in affected individuals with Type 1 diabetes (T1DM).Methods: Individuals with T1DM and SH (defined as hypoglycaemia requiring third party intervention within the preceding 12 months) were characterised to include screening for other underlying autoimmune disease (coeliac serology, short synacthen and thyroid function tests); a questionnaire to evaluate underlyi...

ea0006dp11 | Diabetes, metabolism and cardiovascular | SFE2003

A Prospective Audit of Triple Therapy in Type 2 Patients

James A , Levy D , Davison R

We conducted a prospective audit of triple therapy in type 2 patients (Dec01 to Dec02). 51 patients on maximal Metformin and sulphonylurea had a Glitazone added. 11 patients were lost to follow up. The remaining 40 patients, 23 Male, 17 Female, mean age 51years (35-66), diabetes mean duration 8.5 years (2-16) had a mean BMI of 33.8 (range 22-47). Mean baselineHbA1C was 9.6% (7.3-12.3%).Parameters measured were blood pressure, height, weight BMI, full blo...

ea0006dp12 | Diabetes, metabolism and cardiovascular | SFE2003

NOW YOU SEE IT, NOW YOU DON'T: A VARIABLE PITUITARY MASS

Lee S , Battersby R , Romanowski C , Newell-Price J

A 44 year old woman presented in November 2000 with a two week history of headaches, vomiting and blurred vision. Past history consisted of type 2 diabetes and migraine. Initial investigation revealed hyponatraemia (sodium 114 mmol/l) and deranged liver biochemistry. ANA, anti dsDNA, cANCA, pANCA, anti Ro, La, RNP, Scl-70, Jo-1, smooth muscle and mitochondrial antibodies were negative. MRI revealed a 13x18x15mm pituitary mass elevating the optic chaism, without evidence of rec...

ea0006dp13 | Diabetes, metabolism and cardiovascular | SFE2003

ASYMPTOMATIC TYPE 1 DIABETES MELLITUS

Thomas C , Krentz A

Type 1 diabetes mellitus is usually believed to present acutely and it is assumed that metabolic decompensation is sudden.We present 3 cases of asymptomatic type 1 diabetesCase1A 28 year old asymptomatic gentleman moved to a new surgery and glycosuria was noted as part of routine screening , no ketonuria., body mass index 21, no past medical illness or any family history of diabetes. His fasting blood glucose...

ea0006dp14 | Diabetes, metabolism and cardiovascular | SFE2003

Onset of insulin-resistant stage in a Type II diabetic rat model is associated with diminished levels of vascular endothelial growth factor (VEGF) and its receptors in the penis: implications in the pathogenesis of erectile dysfunction in diabetes

Jesmin S , Sakuma I , Mowa C , Salah-eldin A , Hattori Y , Kitabatake A

The role of vascular endothelial growth factor (VEGF) in the pathogenesis of numerous complications associated with diabetes is well established. However, little is known of VEGF's role in erectile dysfunction (ED), a condition commonly experienced by diabetic men. We hypothesized that expression of VEGF, its receptors and its signaling pathway, Akt, may be altered in diabetic penile tissues and, consequently, induce expression of molecules involved in the development of ED in...

ea0006dp15 | Diabetes, metabolism and cardiovascular | SFE2003

Estradiol Action on Phospholipid Composition of Rat Liver Chromatin

Gevorgyan E , Demirkhanyan L , Artsruni I , #ZhV|#Yavroyan|# , Matinyan K , Hakobyan N

Decondensation of chromatin and the pattern of its packaging in eukariotic nuclei underlie gene expression. It should be outlined that both features are determined not only by the main components of chromatin and nuclear matrix, but also by loosely bound molecules, such as phospholipids, which can interact with nucleoproteins and maintain the degree of chromatin condensation.The steroid hormone estradiol induced changes both of total phospholipid and ind...

ea0006dp16 | Diabetes, metabolism and cardiovascular | SFE2003

An Audit of Initial Management of Thyroid Nodules in secondary care

Ibrahim I , Perros P , Jones N

Fine needle aspiration biopsy (FNAB) is the investigation of choice for patients with thyroid nodules in secondary care. Ideally the following standards should be met: assessment within 2 weeks of referral; FNAB performed in the first visit; consent obtained and documented; communication of the result in person.A cohort of 64consecutive patients (57 female) was identified. The median age was 49 (16-78). Thyroid function tests were normal in 89% of patien...

ea0006dp17 | Diabetes, metabolism and cardiovascular | SFE2003

THE EFFECT OF MATERNAL NUTRITION DURING THE FIRST OR SECOND HALF OF GESTATION ON GLUCOSE TOLERANCE OF THE SOW

Corson A , Litten J , Perkins K , Laws J , Clarke L

In humans, pregnancy is considered a diabetogenic event1. A similar situation occurs in sows1. The amount of fat in the sows' diet is inversely correlated to glucose clearance time, thus modifying glucose tolerance2. The aim was to investigate the influence of altered maternal diet during gestation (term = 115days) on the glucose tolerance of the sow. Thirty-four pregnant sows were randomly allocated to 4 isocaloric diets for either the first (G1) or second (G2) 60 days of ges...

ea0006dp18 | Diabetes, metabolism and cardiovascular | SFE2003

PHAEOCHROMOCYTOMA AND MULTIFOCAL GASTROINTESTINAL STROMAL TUMOURS:CARNEY TRIAD VARIANT OR A NEW SYNDROME?

Zachariah S , Bano G , Nussey S

Case: A GP with autoimmune hypothyroidism presented with a phaeochromocytoma during labour at the age of 36 y. A left adrenalectomy confirmed the diagnosis and a basal cell carcinoma was also removed. She had a history of Dupuytren's lesions of both soles and palms starting in her teenage years and multiple keratosis. There was no family history of any endocrine or skin disorder. At 41y, a benign breast lump was removed and also a gastrointestinal spindle cell stromal tumour (...

ea0006dp19 | Diabetes, metabolism and cardiovascular | SFE2003

Effect Of The Mode Of Conception On Incidences Of Apoptotic And Proliferative Cells In Full Term Human Placentas

Basir G , Cheung P , Cheung A , Lao T

Objectives: To compare the cell dynamics of term placental tissue in pregnancies conceived by in-vitro fertilization (IVF) and embryo transfer with spontaneous pregnancies.Methods: Placental samples were obtained from singleton term IVF pregnancies (n=25) and singleton term spontaneous pregnancies (n=30). Ethical approval was obtained from the Faculty of Medicine, The University of Hong Kong. The incidence of apoptotic and proliferative cells was determi...

ea0006dp20 | Diabetes, metabolism and cardiovascular | SFE2003

PITUITARY METASTASIS FROM AN UNKNOWN PRIMARY

Swamy A , Scobie I

Symptomatic pituitary metastasis is an uncommon presentation of primary carcinoma. We report a case of a 65 years old lady who presented with a six week history of headache and diplopia and a five day history of diarrhoea and vomiting. She also suffered from osteoporosis. She had undergone a hysterectomy for a fibroid. Examination revealed diplopia in all directions of gaze, no papilloedema and an unremarkable systemic examination. Brain MRI showed a contrast enhancing pituita...

ea0006dp21 | Diabetes, metabolism and cardiovascular | SFE2003

An Audit On Adherence To Renal Guidelines in Prevention and Early Management of Renal disease in Type 2 Diabetes

Srinivasan R , Thomson G , Kumar V , Fernando D

IntroductionRenal disease in type 2 diabetes can be prevented and limited with early detection and management of the condition. We studied the adherence of renal guidelines introduced by national institute of clinical excellence (NICE), in patients who attended the annual review in the last 12 months.MethodsAudit standards were based on guidelines for Prevention and Early Management of Renal disease in Type 2...

ea0006dp22 | Diabetes, metabolism and cardiovascular | SFE2003

A Case of ACTH Secreting Benign Mediastinal Carcinoid with Hypocalcaemia

Goulden P , Spring M

This 42-year-old male presented with a six-month history of general lethargy and mood changes. He had experienced weakness & difficulty climbing stairs; weight loss; ankle swelling and increased frequency of micturition. There was no significant past medical history.Initial investigations revealed Na+ 144mmol/L (135-145);K+ 2.3mmol/L(3.5-5.2); U 8.8mmol/L (2.6-6.7); Cr 75μmol/L (60-125); TCO2 41mmol/L (21-31); Fasting glucose 7.4mmol/L; TSH 0.21mU...

ea0006dp23 | Diabetes, metabolism and cardiovascular | SFE2003

Use of Continous glucose monitoring system in the medical management of insulinomas

Baldeweg S , Hope S , Tibbals J , Davidson B , Vanderpump M

The continuous glucose monitoring system (CGMS) have recently been developed for use in diabetes to provide comprehensive blood glucose data around the clock during normal activities. We have demonstrated for the first time that CGMS can assist in the management of 2 patients with confirmed insulinomas. We present 2 female patients (aged 41 and 35 years) with symptoms suggestive of hypoglycaemia. Both had biochemical evidence of insulinoma with hypoglycaemia, hyperinsulinaemia...

ea0006dp24 | Diabetes, metabolism and cardiovascular | SFE2003

Evidence for a cholinergic defect in the brain of the obese-diabetic (ob/ob) mouse

Suri S , Scriven H , Lintern M , Bailey C , Smith M

Central cholinergic defects, as well as cognitive impairments, have been reported in humans with non-insulin-dependent diabetes mellitus (NIDDM). The levels of acetylcholine are partly controlled by the activity of acetylcholinesterase (AChE) which breaks it down. We have previously reported evidence for abnormal AChE activity in the skeletal muscles of the obese diabetic (ob/ob) mouse which provides a model for NIDDM. The aim of the present study was to investigate the levels...

ea0006dp25 | Diabetes, metabolism and cardiovascular | SFE2003

Effect of β-endorphin on glucose uptake and muscle fatigue in resting and contracting muscles of normal and obese-diabetic (ob/ob) mice

Evans A , Khan S , Bailey C , Smith M

We have previously shown that β-endorphin reduces muscle fatigue and increases glucose uptake in contracting and non-contracting skeletal muscles of the mouse. The aim of this study was to compare the effect of these peptides on glucose uptake and muscle fatigue in normal mice and obese-diabetic mice (which provide a model for non insulin-dependent diabetes mellitus, NIDDM). The uptake of glucose into contracting and non-contracting muscle was assessed using the non-metab...

ea0006dp26 | Diabetes, metabolism and cardiovascular | SFE2003

SERUM C-REACTIVE PROTEIN (CRP) IS RELATED TO AGE AND BODY MASS INDEX (BMI) IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME (PCOS) BUT NOT TO INSULIN SENSITIVITY

Laing I , Yates A , Mather E , Pickersgill M

PCOS is associated with increased biochemical risk markers for cardiovascular disease, particularly low HDL cholesterol and increased triglycerides. There is accelerated progression to type 2 diabetes and hypertension in middle age. These biochemical abnormalities associate with insulin resistance which is present to a greater extent than can be explained by obesity alone. Notwithstanding, hard endpoint data in terms of increased cardiovascular mortality remains elusive. Infla...

ea0006dp27 | Diabetes, metabolism and cardiovascular | SFE2003

DOES INSULIN FORMULATION MATTER IN ANTENATAL DIABETES CARE?

Kumar J , Baynes K , Pender S , Lowy C , Jones R , Carroll P

Aim: To assess usage of newly available rapid-acting insulin analogues in the antenatal diabetes clinic, and to determine whether introduction of these agents has influenced glycaemic control.Methods: We analysed our diabetes antenatal clinic attendances from April 2002 to June 2003 using the DIABETA 3 database. 290 pregnant women were seen over this period which was divided into three groups: Group I (April to September 2002), Group II (October 2002 to ...

ea0006dp28 | Diabetes, metabolism and cardiovascular | SFE2003

Prevalence and Management of Cardiovascular disease in a Diabetic-Renal cohort

Jayapaul M , Messersmith R , Bennett-Jones D , Mead P , Large D

Cardiovascular disease is the leading cause of morbidity and mortality in patients with diabetic renal disease. We did a retrospective study on our Joint Diabetic-Renal clinic, which has run for 12 years, to see if we could reproduce targets from clinical trials and local guidelines in routine practice for management of cardiovascular risk. We collected data using clinical notes and electronic records on 133 patients. Our cohort included 62% type 2 and 38% type 1 Diabetics. Me...

ea0006dp29 | Diabetes, metabolism and cardiovascular | SFE2003

Spontaneous differentiation of mouse embryonic stem cells into an islet phenotype

Milne H , Burns C , Minger S , Persaud S , Jones P

Embryonic stem cells (ES cells) represent a population of self renewing pluripotent cells, capable of differentiating into derivatives of the 3 embryonic germ layers and are therefore a promising source material for generation of replacement pancreatic beta cells for transplantation in type 1 diabetes. ES cells can be induced to undergo unregulated differentiation when cultured as floating clusters (embryoid bodies). Successful generation of pancreatic endocrine cells from ES ...

ea0006dp30 | Diabetes, metabolism and cardiovascular | SFE2003

What is the Clinical Relevance of Macroprolactinaemia? A Clinical Case Report

Boyle J , McLellan A

The clinical relevance of macroprolactin and its prevalence among those with 'hyperprolactinaemia' are unclear(1). Macroprolactinaemia has often been described as asymptomatic, benign and not related to pituitary disease(2,3,4). Recent reports, however, suggest that macroprolactinaemia is common among those with 'hyperprolactinaemia', can often be symptomatic and may be occasionally associated with pituitary adenoma(5,6). Pituitary imaging has been recommended in all symptomat...

ea0006dp31 | Diabetes, metabolism and cardiovascular | SFE2003

Bicuspid Aortic Valve is associated with increased arterial stiffness in adult women with Turner Syndrome

Ostberg J , Donald A , Storry C , Lloyd N , McCarthy C , Halcox J , Conway G

IntroductionCardiovascular disease, which may be structural or ischaemic, is the major cause of morbidity and mortality for women with Turner Syndrome (TS). This study investigated arterial augmentation index (AI%) and pulse wave velocity (PWV) as measures of arterial stiffness in adults with TS. A more positive AI% and greater PWV indicate increased arterial stiffness.Method66 women with TS and 8 normal wome...

ea0006dp32 | Diabetes, metabolism and cardiovascular | SFE2003

Normal Synacthen Test response and Evolution of Schmidt's Syndrome in brittle Type 1 Diabetes

Ahmed A , Winocour P

BackgroundIdiopathic Addisons disease is characterised by the presence of adrenal antibodies and a documented variable subclinical period. In previously well controlled Type 1 diabetes, it may present with recurrent hypoglycaemia, or worsening erratic glycaemic control.Case ReportA 24 year old with previously well controlled Type 1 diabetes since age 18 months presented with worsening glycaemic control, 2 sto...