UKINETS2024 22nd Annual Meeting of the UK and Ireland Neuroendocrine Tumour Society 2024 Poster Presentations (33 abstracts)
Retrospective study evaluating factors influencing cancer recurrence following surgical resection of pancreatic neuroendocrine tumours (PanNETs)
Zaira Rehman 1 , Emily Freeman 2 , Chris Davies 2 , Alex Boyd 1 , Ian Geh 1 , Mohammed El-Sayed 1 , Simon Hughes 1 , Shishir Shetty 1 , Selva Selvaraj 1 , Mona Elshafie 1 , John Ayuk 1 , Bobby Dasari 1 & Tahir Shah 1
1Queen Elizabeth Hospital, Birmingham, United Kingdom. 2Birmingham Medical School, Birmingham, United Kingdom
Introduction: Pancreatic neuroendocrine tumours (PanNETs) are the second most common form of pancreatic cancer. Lesions larger than 2 cm are commonly selected for surgical clearance according to the European Neuroendocrine Tumour Society (ENETS) guidelines. In this study, we assessed the variables that may affect recurrence following resection of PanNETs.
Methods: All the patients who underwent resection of PanNET over a 5-year periods between 2017 – 2022 at a NET COE were included. Variables assessed included age at diagnosis, lesion size, location of the mass, and post-operative complications. Univariate statistical analyses were performed, with independent t-tests used for continuous variables (age at diagnosis, lesion size) and a chi-square test applied for categorical variables (post-operative complications). Individuals with grade 3 NEC or known metastases prior to operation were excluded.
Results: A total of 58 patients who underwent resection for pancreatic cancer was analysed. Patients were categorised into two groups based on the presence (15.5%, 9 patients) or absence (84.5%, 49 patients) of cancer recurrence. Size of the lesion was significantly associated with recurrence (P = 0.014). Patients with recurrence had a mean lesion size of 7.11 cm (SD = 4.40 cm), compared to 3.71 cm (SD = 3.55 cm) in patients without recurrence. Age at diagnosis (P = 0.289) did not have a statistically significant influence on recurrence. Post-operative complications were significantly associated with recurrence (P = 0.029), with 77.8% of patients who experienced recurrence having complications. The most common complications included pancreatic leaks, adhesional obstructions, infections (sepsis, pyrexia) and incisional hernias.
Conclusion: Lesion size and post-operative complications appear to significantly influence the likelihood of cancer re-occurrence in patients undergoing resection for PanNETs. These findings will help in appropriate selection of patients for resection of PanNETs.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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