Endocrine Abstracts

Background: Currently there is limited availability of 68Ga-DOTATATE in the UK due to limited radiopharmaceutical production. New whole-body PET/CT scanners with higher sensitivity may allow administered activities lower than the recommended 100-200MBq by international guidelines, potentially allowing more patients to be imaged from an elution vial.Aim: To evaluate the feasibility of reducing administered tracer activity on a whole-body scanne...

Background: Pancreatic Enzyme Insufficiency (PEI) is a recognised potential consequence of pancreatic pathology and / or somatostatin analog therapy. It is known to be detrimental to patient quality of life and nutritional status (1). Patients with PEI can experience gastrointestinal symptoms, vitamin and micronutrient deficiencies, malnutrition, and even reduced survival (2). Pancreatic enzyme replacement therapy (PERT) is the expert guideline recommended treatment for PEI, a...

Introduction: The mean time from onset of symptoms to diagnosis in NEN is around 5-7 years. Late stage NEN is often diagnosed during an emergency admission. The difference in overall survival (OS) between emergency and elective diagnoses has not been studied. This study assesses factors associated with emergency presentation (EP) versus routine presentation (RP), evaluates factors associated with late presentation, and correlates these with OS. Methods: ...

Introduction: TNM 8 is the staging system for GEP-NEN, guiding prognosis and treatment. However, it ignores important prognostic factors including age, sex, race, tumour site, and morphology.Methods: 35,347 adults diagnosed between 2011-2021 with GEP-NEN and had no missing data in any variables were extracted from SEER. Age, sex, race, tumour site, size, morphology, number of lymph nodes and metastasis site were used to create 3 clusters using K-means ML...

Introduction: Liver-directed therapies are an important component of palliative control of disease burden and carcinoid syndrome for unresectable liver metastases of neuroendocrine tumours. Hepatic artery embolization (HAE) and selective internal radiotherapy (SIRT) are both available loco-regional therapies however there is currently no consensus on which should be offered. We looked to compare HAE against SIRT and their impact on survival. Methods: Thi...