Endocrine Abstracts

Introduction: Radioactive iodine treatment (RAI) of thyroid pathologies contributes to endocrine and metabolic complications. Cardiovascular disease (CVD) is a leading cause of mortality and morbidity worldwide. Identification of the subpopulations with a higher risk of developing CVD and lipid metabolic disorders is crucial, particularly in Graves patients.

Aim: This study aimed to investigate the usefulness of new anthropometric indices such as BAI, VAI, LAP, BRI, ABSI and new atherogenic indices such as TyG index, TyG-BMI index, TyG-WC index in the evaluation of lipid parameters in patients with Graves disease.

Material and methods: The study enrolled 49 women and men aged 20-49. Criteria for selecting the subjects were as follows: diagnosed Graves disease after TRAB positive. Blood samples were taken from patients after 6 months of RAI. Biochemical parameters (total cholesterol, HDL, LDL, TG) were determined and used for the calculation of atherogenic indices. Anthropometric parameters were measured with the use of standard methods in the morning. These measurements included body weight, height, waist circumference, and hip circumference. After this step, anthropometric indices such as BAI (Body Adiposity Index), VAI (Visceral Adiposity Index), LAP (Lipid Accumulation Product), BRI (Body Roundness Index), ABSI (Body Shape Index), AIP (Atherogenic risk of plasma) were calculated. The study was reviewed by the local bioethics committee.

Results: There was observed a significant positive relationship between BAI, VAI, LAP, BRI, ABSI, TyG index, TyG-BMI index, TyG-WC index and LDL cholesterol and triglycerides (P < 0.005).

Conclusion: Analyzed new anthropometric indices and new atherogenic indices have demonstrated a significant relationship with lipid profile in graves disease patients. These indices may be useful tools in predicting metabolic disorders in patients after radioactive iodine treatment.