Endocrine Abstracts

The prevalence of type 2 diabetes (T2DM) in pregnancy is increasing rapidly worldwide. Most guidelines for diabetes during pregnancy are based on studies in women with type 1 diabetes (T1DM) and as a result, there is an urgent need to improve the knowledge of pregnant women with T2DM. As pregnancy induces insulin resistance in maternal tissues the insulin resistance might be worse in pregnant women with T2DM in the light of the pathophysiology of T2DM, where insulin resistance...

Hybrid closed-loop systems providing automated glucose responsive insulin delivery are set to revolutionise the management of type 1 diabetes. However, pregnancy poses formidable challenges, including more stringent glucose targets, gestational changes in insulin sensitivity and day to day variations in insulin pharmacokinetics. Therefore, hybrid closed-loop systems that are effective outside pregnancy, cannot guarantee clinically relevant glycaemic benefits throughout pregnan...

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