Endocrine Abstracts

Osteoporosis is a condition characterised by bone loss, architectural deterioration and increased susceptibility to fractures, which cause substantial pain and limitations in function. One in two women, and one in five men, aged over 50 will experience a fracture in their remaining lifetime. Exercise may reduce risk of osteoporotic fracture by increasing bone strength and reducing risk of falls, which precipitate many osteoporotic fractures. The types of exercise effective on ...

Bone remodelling is regulated by many endogenous factors, with recent attention on the pivotal role of gut-derived peptide hormones in this regard. Indeed, a gut-bone axis has now been described, that is coordinated largely by the secretion and action of intestinal-derived peptide hormones. In addition to this, obesity and diabetes are highly prevalent metabolic disorders that negatively affect health, and there is now a clear link between these diseases and impaired bone heal...

Bone marrow adipose tissue (BMAT) is a distinct, major adipose tissue subtype that is a normal feature of mammalian anatomy. However, BMAT’s pathophysiological functions and genetic determinants remain unknown. In humans, bone marrow adiposity is typically measured as the bone marrow fat fraction (BMFF) using magnetic resonance imaging (MRI). Herein, we used deep learning to measure the BMFF of the spine, femoral head, total hip, and femoral diaphysis from MRI of >45,...