SFEIES24 Poster Presentations Thyroid (21 abstracts)
Selenium prescribing for thyroid eye disease in NI – the exponential rise
Muhammad Aamir Shahzad 1,2 , Ailish Nugent 1 , Amy Hunter 1 , Anthony Lewis 1 , Ben Loughrey 1 , Doua Ahmed 1 , Geraldine Casey 1 , Claire McHenry 1 , Hamish Courtney 1 , Helen Wallace 1 , Ian Wallace 1 , John Lindsay 1 , Milad Darrat 1 , Philip Johnston 1 , Rizwan Haq 1 , Robert D’Arcy 1 , Sri Kamalarajah 1 , Steven Hunter 1 , Steven White 1 , Una Graham 1 , Bernadette McNabb 2 , Fred McElwaine 2 , Paul McMullan 2 , Roy Harper 2 , Samah Elhassan 2 , Muhammad Shakeel Majeed 2 , Ghulam Mustafa Shaikh 2 , Andrew Neely 3 , Anna Todd 4 , Farooq Sandhu 4 , Jayna Smyth 4 , Una Bradley 4 , Mae McConnell 4 , Adele Kennedy 5 , Ali Hameed 6 , Connor Hamill 5 , Des Rooney 5 , Edward McKeever 7 , Emma McCracken 7 , Neil Black 8 , Rhys Kelly 8 , Barry Cartmill 8 , Efstathios Bonanos 2 , Aileen Gordon 9 , Jayne Woodside 10 & Karen Mullan 1
1Belfast Health and Social Care Trust, Belfast, United Kingdom; 2South Eastern Health and Social Care Trust, Belfast, United Kingdom; 3Southern Health and Social Care Trust, Newry, United Kingdom; 4Southern Health and Social Care Trust, Craigavon, United Kingdom; 5Northern Health and Social Care Trust, Antrim, United Kingdom; 6Northern Health and Social Care Trust, Coleraine, United Kingdom; 7West Health and Social Care Trust, Enniskillen, United Kingdom; 8West Health and Social Care Trust, Londonderry, United Kingdom; 9Business Service Organization, Belfast, United Kingdom; 10Queen’s University Belfast, Belfast, United Kingdom
Selenium (Se) supplementation is recommended by the European Group (EUGOGO) for mildly active TED (200 mg/day for six-months) based on a seminal RCT which reported slowing of disease progression vs placebo. Treatment in Se deficient geographical areas may be particularly important. We recently reported Se deficiency in a cohort of 240 pregnant women in NI. The TEAMeD-NI group was set up in 2019 as part of the UK-wide quality improvement program to take a proactive approach to TED and it is the first QI of its kind in Europe. The BNF currently recommends Se use for deficiency states (eg inborn-errors) but does not mention TED. In NI, prescriptions from secondary care to GP are advisory only and the Business Services Organisation has collected GP script data since 2010. There were no GP Se scripts from 2010 to 2016. Since then, 244 patients have been prescribed Se with year on year increases (eight-fold higher in 2023 vs 2017). Anti-thyroid drugs were dispensed in at least 72% at some point (records since 2010). In 2023, 129 patients received Se scripts (78% female, modal age 45-54 years and 63% with anti-thyroid medication scripts in same year). Given the BNF status, OTC Se was initially recommended. However in 2017 GP scripts began in the West and Southern Trusts and all other Trusts quickly followed. The majority of scripts are for patients in the most socially deprived quintiles. Given the rare alternative indications for Se (zero scripts up to 2016), GP scripts may be a useful surrogate marker of our increasingly proactive management of TED in NI. The data also demonstrates the positive relationships that exist between secondary care and our GP colleagues in NI. This has likely improved Se accessibility for patients in the most socially deprived areas who can least afford OTC supplements.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more