Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

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Joint Irish-UK Endocrine Meeting 2024

Belfast, Northern Ireland
14 Oct 2024 - 15 Oct 2024

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Poster Presentations

Reproductive Endocrinology

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ea0104p185 | Reproductive Endocrinology | SFEIES24

Abstract withdrawn...
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ea0104p186 | Reproductive Endocrinology | SFEIES24

Case of young man with waardenburg and kallmann syndromes with unexpected reversibility of hypogonadism- a SOX 10 story

Hunter Amy , Donnelly Deirdre , Mullan Karen

Waardenburg syndrome type-II is characterised by sensorineural deafness and skin/ hair hypopigmentation due to pathogenic variants in SOX10 gene. SOX10 protein is a transcription factor regulating early neural crest-cell development. Recently SOX10 pathogenic variants have been described in a small number of patients with both Waardenburg and Kallmann Syndrome (hypogonadotropic hypogonadism (HH), anosmia) indicating co-pathogenicity. An 18 year old male presented with delayed ...
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ea0104p187 | Reproductive Endocrinology | SFEIES24

Unusual endocrine end organopathy in primary haemochromatosis

Uchupalanun Aurisa , Baskar Varadarajan

Background: Hereditary Haemochromatosis causes iron build up in various organs. Endocrine organs are a known target for iron accumulation, secondary only to the liver. Hypoparathyroidism from parathyroid involvement is a rarely recognised entity with its mechanism still not fully understood. Case Description: We report a case of a 38-year old, otherwise fit and well, male diagnosed with hereditary haemochromatosis due to family screening managed with reg...
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ea0104p188 | Reproductive Endocrinology | SFEIES24

The neural bases underlying distressing low sexual desire is sex specific

Tsoutsouki Jovanna , Ertl Natalie , Mills Edouard , Wall Matt , Thurston Layla , Yang Lisa , Suladze Sofiya , Hunjan Tia , Phylactou Maria , Patel Bijal , Bassett Paul , Howard Jonathan , Abbara Ali , Golmeier David , Comninos Alexander N. , Dhillo Waljit S.

Background: Hypoactive Sexual Desire Disorder (HSDD) affects 10% of women and 8% of men. In women, the ‘top-down’ neurofunctional HSDD model suggests that hyperactivation of higher-level cognitive brain regions suppresses lower-level sexual brain activity in response to erotic cues, impairing sexual function. Conversely, the neurodysfunction in men with HSDD is not fully characterised and unlike in women where therapies exist, there are no licensed pharmacotherapeuti...
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ea0104p189 | Reproductive Endocrinology | SFEIES24

Is there an association between daylight hours and serum testosterone levels in men?

Livingston Mark , Heald Adrian , Hackett Geoff , Ramachandran Harishnath , Ramachandran Sudarshan

Introduction: Studies assessing variability of serum testosterone levels associated with seasonal environmental factors have been contradictory. We assessed associations between the seasons and changes (δ) in seasonality indices and male serum total testosterone (δTT) variability.Methods: Data were collected in 144 men with paired serum TT samples (126 non-fasting/18 fasting) analysed at Walsall Manor Hospital, UK (52.3 degrees...
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ea0104p190 | Reproductive Endocrinology | SFEIES24

Leveraging genomic-based machine learning to discover bioactive molecules that alleviate symptoms of polycystic ovary syndrome

Olabode Ayomide , Hanassab Simon , Southern Joshua , Izzi-Engbeaya Chioma , Heinis Thomas , Abbara Ali , Veselkov Kirill , Dhillo Waljit

The pathophysiology of Polycystic Ovary Syndrome (PCOS) is multifactorial, therefore discovering effective treatments is challenging. Bioactive food molecules are a potential avenue for PCOS treatment; however, they often lack robust evidence. Applying machine learning (ML) to a genomic dataset may provide accelerated discovery of molecules and drugs that potentially alleviate symptoms through interactions with PCOS-related genes. 17,600 genes, 2,100 bioactive molecules found ...
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ea0104p191 | Reproductive Endocrinology | SFEIES24

Impact of synthetic estrogen ethinylestradiol on endometrial morphology and function in diet-induced obese mice

Mc Guigan Orla , Sridhar Ananyaa , Khan Dawood , Flatt Peter R. , Moffett Charlotte R.

Background/aims: Obesity is a major risk factor for endometrial cancer with estrogens in combined oral contraceptives enhancing the severity of the disease. This study aims to explore the effect of synthetic estrogen ethinylestradiol (EE2) commonly used in oral contraceptives, on endometrial morphology and regulatory markers in diet-induced obese mice.Methods: Female TO mice were on a high-fat diet (HFD) for 27 weeks. Three groups (n = 5) were g...
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ea0104p192 | Reproductive Endocrinology | SFEIES24

Diabetes as an independent risk factor for endometrial carcinoma

Karabaeva Zebo , Shamansurova Zulaykho

Introduction: Diabetes mellitus (DM) has become a global health concern, associated with increased mortality and morbidity rate. The escalating incidence of DM, particularly type 2 DM (T2DM), aligns with the rising rates of various cancers, hinting at a plausible direct connection between DM and cancer. Mounting evidence suggests that DM may contribute to the heightened incidence of endometrial cancer (EC) and underscores its correlation with poor prognosis. Individuals with D...
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ea0104p193 | Reproductive Endocrinology | SFEIES24

Association of PCOS related metabolite glycoprotein acetyls with gestational diabetes and preeclampsia in the born in bradford study

Deshmukh Harshal , Sathyapalan Thozhukat

Introduction: Glycoprotein Acetyls (GlycA), is a marker of systemic inflammation, we have recently shown its association with pregnancy in Polycystic Ovary Syndrome (PCOS). This study aims to investigate the association between GlycA levels and the risk of gestational diabetes mellitus (GDM) and preeclampsia in the Born in Bradford (BiB) cohort.Methods: The Born in Bradford study is a UK-based longitudinal birth cohort. We performed profiling of circulat...
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ea0104p194 | Reproductive Endocrinology | SFEIES24

Multi-receptor activation by (GIP-GCG-GLP-1) triple agonist regulates female reproductive function in diet induced obese mice

Sridhar Ananyaa , Khan Dawood , Flatt Peter , Moffett Charlotte

Background/Aims: Emerging evidence suggests that gut hormones interact with the reproductive axis and impact fertility in females. Here we combine three major gut hormones glucose-dependent insulinotropic peptide (GIP), glucagon (GCG) and glucagon-like peptide-1 (GLP-1), as a triple-agonist (TA) to elucidate its effects on female reproductive function.Methods: Female Swiss TO-mice (n = 6) on high-fat diet (HFD) or normal diet (ND) for 18-weeks r...
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ea0104p195 | Reproductive Endocrinology | SFEIES24

Mapping the anatomical and transcriptional landscape of early human fetal ovary development

McGlacken-Byrne Sinead , Del Valle Ignacio , Xenakis Theodoros , Simcock Ian C. , Suntharalingham Jenifer P. , Buonocore Federica , Crespo Berta , Moreno Nadjeda , Liptrot Danielle , Niola Paola , Brooks Tony , Conway Gerard , Dattani Mehul T. , Arthurs Arthurs Owen J. , Solanky Nita , Achermann John

Context: The complex genetic mechanisms underlying human ovary development can give rise to clinical phenotypes if disrupted, such as Primary Ovarian Insufficiency and Differences of Sex Development. In recent years, RNA sequencing (RNAseq) approaches have characterised ovary development in previously unparalleled detail; however, a challenge is synthesising and using these data to advance our understanding of clinical disease.Methods: We combine single-...
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ea0104p196 | Reproductive Endocrinology | SFEIES24

Single-nucleus rna-sequencing reveals novel potential mechanisms of ovarian insufficiency in 45,x turner syndrome

McGlacken-Byrne Sinead , Del Valle Ignacio , Xenakis Theodoros , Suntharalingham Jenifer P. , Nel Lydia , Liptrot Danielle , Crespo Berta , Ogunbiyi Olumide K. , Niola Paola , Brooks Tony , Solanky Nita , Conway Gerard S. , Achermann John C.

Background: Turner syndrome (TS) is the most common genetic cause of Primary Ovarian Insufficiency (POI). Morphological analyses of human fetal 45,X ovaries have demonstrated germ cell apoptosis by 15-20 weeks post conception (wpc). However, we do not know why POI develops mechanistically. Here, we use single-nuclei RNA sequencing (snRNA-seq) and bulk RNA sequencing to identify novel potential mechanisms of ovarian insufficiency in TS and to characterise X chromosome gene expr...
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ea0104p197 | Reproductive Endocrinology | SFEIES24

Tertiary centre experience of testosterone prescribing in menopause clinic

Brewster Rosalind , Strong Sophie , Boyd Hannah , Khanjani Shirin , Talaulikar Vikram , Clarke Sophie A. , Shahid Anupama

Objective: To determine tertiary care practice of prescribing testosterone to women attending menopause clinic and to assess its tolerability and side effects.Methods: Retrospective electronic notes review of patients attending the University College London Hospital (UCLH) menopause clinic between 2019-2023 and Whipps Cross Hospital (WCH) menopause clinic between Jan 2021-July 2023. Patients prescribed testosterone were identified and included.<p cla...
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ea0104p198 | Reproductive Endocrinology | SFEIES24

Evaluation of the myo-inositol effect in treating infertility among patients with polycystic ovary syndrome

Mamadjanova Kamila , Mamadjanova Shakhnoz , Shamansurova Zulaykho

Polycystic ovary syndrome (PCOS) is a hormonal imbalance caused by ovarian dysfunction representing one of the most common endocrine metabolic disorder in reproductive aged women. PCOS is highly correlated with resistance to insulin and abnormal increase of androgen levels. Myo-inositol (MI) supplementation in women with PCOS has been evaluated over the last years. Many hormonal and reproductive dysfunctions associated with this disorder have been proven to be relieved by the ...
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ea0104p199 | Reproductive Endocrinology | SFEIES24

The GNRHR mutation: from delayed puberty to normosmic hypogonadotropic hypogonadism

Iakovou Angeliki , Yang Sim Sing

A gentleman in his 20s, was referred to the endocrinology clinic due to delayed puberty with absent secondary sexual characteristics and low total testosterone level 1.7 nmol/l (8.64-29), and free testosterone 38 pmol/l (198-619). He had no past medical history or drug history. He reported no anosmia and no family history of delayed puberty. However, he had an 11 year-old brother who remained pre-pubertal. On further questioning, he had no secondary sexual characteristics such...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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