SFEIES24 Poster Presentations Neuroendocrinology (30 abstracts)
Effect of endoscopic transsphenoidal surgery on pituitary function – preliminary report from a tertiary referral centre
Julie Okiro , Niamh Kyne , Ibrahim Ibrahim , Merah AlBusaidy , Raymond Fuller , Aneel Vaswani , Claire Carthy , Donncha O’Brien , Gulam Zilani , Mohsen Javadpour & Amar Agha
Beaumont Hospital, Dublin, Ireland
Limited data are available on the effect of transsphenoidal surgery using the endoscopic method on pituitary function. In this preliminary report we retrospectively evaluated the frequency of pituitary failure and recovery in a population of patients who underwent this procedure over a 12 months period. 42 (21 women) consecutive adult patients were included. 29 patients had non-secretory pituitary neuroendocrine tumours, the rest had secretory tumours and other non-adenomatous pituitary region masses. 29 patients had optic chiasma compression. Pituitary function was assessed using baseline and dynamic testing. Of the 35 patients who had full gonadal function assessment, 20 had preoperative deficiency with six showing recovery and four developing new deficiencies postoperatively. 23 patients had dynamic hypothalamo-pituitary-adrenal (HPA) axis assessment with three showing preoperative deficiency, six developing postoperative deficiency and none showing recovery. 10 of 40 patients assessed showed preoperative TSH deficiency with two developing new deficiency and four showing recovery postoperatively. Four patients had preoperatively AVP deficiency with no recovery and no new cases postoperatively. GH deficiency was assessed in only four patients preoperatively and persisted in all four patients postoperatively. This preliminary report showed that a minority of patients develop pituitary deficits following endoscopic transsphenoidal surgery while some recover. These data will help to counsel patients undergoing this procedure. Larger study is necessary for definitive conclusions.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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