Endocrine Abstracts

Non-islet cell tumor hypoglycemia (NICTH) is a rare phenomenon that is likely mediated by insulin growth factor 2 (IGF-2). IGF-2 excess results from tumor overproduction of either mature IGF-2 or incompletely processed IGF-2 (“big IGF-2”), which binds to the insulin receptor causing hypoglycemia. We present a case of IGF-2 mediated hypoglycemia secondary to adrenocortical carcinoma, as well as a series of 8 previously published cases. An 83-year-old male with a histo...

Introduction: The BRAF V600E mutation has been reported in 27– 90% of Papillary Thyroid Carcinoma (PTC). BRAF V600E may be associated with adverse outcomes in PTC. It is unknown if detection of BRAF V600E can play a key role in prognosis, and can be used as a surrogate-marker of poor outcomes in PTC.Objectives: • To investigate prevalence of BRAF V600E mutation in TC using digital droplet PCR (ddPCR)....

Background: Paragangliomas are rare neuroendocrine tumours of the sympathetic and parasympathetic paraganglia. Optimal outcomes are dependent on careful investigation, management and follow-up.Aim: The aim of this audit was to review clinicopathological characteristics of a cohort of operated abdominal paragangliomas in Northern Ireland.Methods: This is a retrospective audit of abdominal paragangliomas from the Northern Ireland reg...

Background: Immune checkpoint inhibitors (ICI) are anti-cancer drugs associated with adverse events that results from releasing the immune system against self-antigens while attacking cancer cells. Multiple endocrine dysfunctions have been associated with administration, including hypophysitis, thyroid disorders and diabetes.Case report: We report the case of a 57-year-old female, diagnosed with melanoma of the left arm Barlow Depth 2 mm, receiving treat...

Background: Intensity-modulated radiotherapy (IMRT) precisely delivers radiation to brain tumours while partially sparing surrounding structures like the hypothalamic-pituitary axis. The risk of hypopituitarism in survivors of adult-onset, primary, non-pituitary brain tumours following IMRT is poorly understood.Methods: We conducted a retrospective cohort study of brain tumour survivors undergoing endocrine surveillance in Beaumont Hospital. Patients wit...

Adrenocortical carcinoma (ACC) carries a 5-year prognosis of <10%. Therapeutic options are limited including surgery and mitotane – a poorly tolerated and efficacious insecticide. Recent data have demonstrated that the immune environment of ACC is deficient in lymphocytes while demonstrating a relative rich monocyte/macrophage population in the tumour microenvironment. We have investigated the migration of circulating monocytes to ACC. ACC cells were seeded in the bot...

Background: Pregnancy outcome after radioiodine treatment for differentiated thyroid carcinoma (DTC) is debated. Some studies found a 23% infertility rate after radioiodine treatment. On the other hand, postoperative radioiodine therapy for DTC had no significant effect on spontaneous abortion, premature, stillbirth and congenital malformation.Aim: To access pregnancy outcome in a series of women with DTC treated with radioiodine postoperatively. <p ...

Background: RET proto-oncogene that encodes receptor tyrosine kinase is responsible for the pathogenesis of most of the thyroid cancer subtypes. Selpercatinib and pralsetinib, both specific RET-kinase inhibitors, are the only two FDA-approved drugs for RET-altered thyroid cancer. We aimed to evaluate the safety and efficacy of these two drugs.Methods: We searched PubMed, Embase, Cochrane and Clinicaltrials.gov databases for RCTs and observational studies...

Introduction: Phaeochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumours that are inherited in at least 40% of cases. The most common pathogenic germline variants (PGVs) implicated in the development of PPGLs are in genes coding for the subunits of succinate dehydrogenase (SDH). PPGLs are heterogenous tumours that have a variable clinical phenotype. Rates of metastatic disease varies from 5-40%. This variability is not currently understood. All patients iden...