SFEIES24 Poster Presentations Diabetes & Metabolism (68 abstracts)
Specific diet and exercise patterns exert discernible effects on acute ketone metabolism in healthy adults: a cross-over observational study
Enda Murphy 1,2,3 , Eabha Walsh 1 , Jessica Sayfullaeva 1 , Salman Alsalem 1 , Aseel Alshogairi 1 , Caitriona Lynch 2 , Tara Kelly 1 , Timothy OBrien 1,2,3 , Martin Leahy 3,4 & Francis Finucane 1,2,3
1School of Medicine, University of Galway, Galway, Ireland; 2Bariatric Medicine Service, Centre for Diabetes, Endocrinology and Metabolism, Galway University Hospitals, Galway, Ireland; 3CÚRAM, SFI Research Centre for Medical Devices, University of Galway, Galway, Ireland; 4School of Physics, National University of Ireland Galway, Ireland, Galway, Ireland
Physiological ketosis may play an important role in human health. We sought to describe, using point of care blood ketone measurements, the time to onset of ketosis (plasma beta-hydroxybutyrate (BHB) ≥0.5 mmol/l) when fasting, and in response to various exercise and dietary scenarios following 12- and 24-hour fasts. Ten healthy female adults had BHB concentrations measured continuously over three hours during three dietary scenarios on separate mornings, after a 12-hour fast: no breakfast, standard carbohydrate breakfast and an isocaloric low carbohydrate breakfast. On a fourth morning, they performed a supervised 60-minute bout of moderate intensity aerobic exercise at 70% of their estimated maximal heart rate. Separately, four healthy participants (2 female) underwent precisely the same set of diet and exercise scenarios, but after a 24-hour, and with the addition of 50% and 90% exercise intensity scenarios. Exercise was associated with a higher ketone concentration area under the curve (AUC) compared to fasting (68± 21 mmol•h/l vs 48±16, mmol•h/l, p = 0.019), low carbohydrate breakfast (43± 14 mmol•h/l p = 0.039) and to standard carbohydrate breakfast (41±11 mmol•h/l p=0.002) following the 12 hour fast. An intensity-dependent inverse effect of aerobic exercise was found with lower ketones at higher intensities, with significant differences observed at high intensity (90% HRmax) to moderate intensity (70% HRmax) exercise (89±20 mmol•h/l vs 183±62 mmol•h/l p = 0.027) following a 24 hour fast. Exercise and dietary scenarios influence circulating ketone concentrations in healthy individuals following either 12 or 24 hours of fasting to an extent that is discernible and detectable with repeated point-of-care measures of blood BHB. Whether quantification of fluctuations in BHB concentrations over time could provide meaningful feedback on diet and physical activity behaviours for people with obesity and related disorders remains to be determined
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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