SFEIES24 Poster Presentations Bone & Calcium (20 abstracts)
Vitamin D insufficiency in parathyroid bone disease
Paul Lavin 1 , Ruth Cullen 2 , Khalid Ahmed 1 , Maria Byrne 1 , Brendan Kinsley 1 , Mensud Hatunic 1 , Siobhan McQuaid 1 , Paula O’Shea 2 & Nigel Glynn 1
1Department of Endocrinology, Mater Misericordiae University Hospital, University College Dublin, Belfield, Dublin 4, Ireland; 2Department of Clinical Biochemistry & Diagnostic Endocrinology, Mater Misericordiae University Hospital, University College Dublin, Belfield, Dublin 4, Ireland.
Background: Vitamin D insufficiency and low bone mineral density (BMD) are common in primary hyperparathyroidism (PHPT). The relationship between Vitamin D status and parathyroid bone disease is worthy of investigation.
Aim: Our aim was to review the medical management of PHPT in an Irish university hospital and perform a sub-group analysis on people with low BMD and vitamin D insufficiency – serum 25OH vitamin D <75 nmol/l (Evaluation and Management of PHPT: Guideline - Fifth International Workshop).
Methods: A retrospective electronic search using the laboratory information system (iSOFT Telepath®) was performed over a 12 month period (2022). We collected clinical, biochemical and radiological data on 58 subjects (43 female). Approval granted from institutional audit committee. Statistical analysis was performed using GraphPad Prism.
Results: Median (SD) adjusted serum calcium was 2.65 mmol/l (0.1); 19% (11/58) had a calcium level >2.85 mmol/l. Median (SD) PTH and serum 25OH vitamin D levels were 10.1 pmol/l (4.1) and 61 nmol/l (35.7) respectively. The results demonstrated that 76% (44/58) of patients had vitamin D insufficiency and 76% (44/58) had low BMD, of which 50% (22/44) had osteoporosis. 59% (13/22) were on treatment for osteoporosis. Following statistical analysis, there was no association between vitamin D status (deficient/sufficient) and low BMD. Furthermore, there was no statistical relationship between BMD and serum adjusted calcium, PTH or vitamin D concentration. 36% (21/58) of patients with vitamin D insufficiency were on vitamin D replacement. Of those with low BMD, 77% (34/44) had a three-site DEXA (including radius). Fracture was recorded in 14% (8/58) - three wrist, three ankle and two miscellaneous - all of whom had a low BMD.
Discussion: Vitamin D insufficiency and low BMD were common in Irish patients with mild PHPT. Parathyroid bone disease is a complex condition. The role of vitamin D deficiency and supplementation to reduce fracture risk require further investigation.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more