Endocrine Abstracts

Self-limited delayed puberty is a condition that is frequently familial with strong genetic determinants. It has been linked to coding region sequence variation by next generation sequencing of affected individuals, identifying genetic regulation of gonadotropin-releasing hormone (GnRH) pathways underlying this condition. However, the role of epigenetic modifiers of human pubertal timing is underexplored. The hypothalamic-pituitary-gonadal axis is unique as it is acti...

Introduction: Cystic prolactinomas were historically considered resistant to dopamine agonists. However, recent case series including one by Faje et al. have highlighted their potential efficacy. We conducted an audit of cystic prolactinomas in Beaumont Hospital to assess this further. Methods: Cystic prolactinomas were defined as a macroadenoma with a cystic component exceeding 50% of the adenoma volume and a prolactin of at least 2,000mIU/l. Data was e...

Introduction: Hyperthyroid Graves’ Disease affects 3% of women and 0.5% of men over a lifetime, with only 50% of patients experiencing remission following antithyroid drug therapy. The humoral immune response involves the production of Thyroid Stimulating Hormone Receptor antibodies (TRAbs) from plasma cells. This study aims to provide proof of principle that Daratumumab, a monoclonal antibody targeting cell-surface CD-38 on plasma cells, could modulate the immune respons...

Background: Glucose-dependent insulinotropic polypeptide (GIP) secreted by K-cells in the intestine is an incretin that stimulates insulin secretion from pancreatic beta-cells. The aim of this study is to explore the extra-pancreatic effects of GIP on male fertility using diet-induced obese mice.Methods: Male Swiss TO-mice (n = 8) on high-fat diet (HFD) or normal diet (ND) for 8-weeks received twice-daily intraperitoneal injections of (...