Endocrine Abstracts

Introduction: Since launching our West Midlands CEW service, we have been supporting children and young people (CYP) and their families with a diverse ethnic background who live in the most deprived areas in the country. The association of obesity and socio-economic deprivation is well reported with its prevalence over twice as high in the most deprived areas and pathways to ethnic differences in obesity have been previously explored. What is less well documented is the intera...

Introduction: Due to the increasing prevalence of childhood obesity, and challenges presented by associated physical and psychological comorbidities, NHS England initiated a pilot to treat Complications from Excess Weight (CEW) in dedicated clinics across the country. Facilitating sufficient face-to-face appointments with increased need for services carries associated costs and greater demand, both on the patient and their families, and on the medical team. To supplement the r...

Introduction: Obesity in children and young people (CYP) can cause various physical disabilities and psychological problems. They are at risk of being stigmatized, leading to poor academic performance and social interactions. It is important to assess the impact of obesity on the lives of CYP through tools such as Health-related quality of life (HRQOL) questionnaires.Aim: Longitudinal assessment of the anthropometric parameters and HRQOL scores at baseli...

Introduction: Childhood obesity, has been linked to several nutritional and genetic factors. In some patients, monogenic causes can be identified, due to single gene mutations in specific pathways related to appetite regulation. One of the most common monogenic causes of obesity is heterozygous mutations in Melanocortin 4 receptor (MC4R), with a prevalence of 2% to 6% in juvenile-onset obesity. We report the effect of Semaglutide (GLP1 analogue) in two adolescent patients with...

Background: Whilst recent systematic reviews have suggested potential benefits to exercise interventions on metabolic outcomes for children and young people (CYP) living with obesity, there is a lack of studies examining the qualitative experiences of CYP as to exercise provision within obesity services. Weight stigma has a negative impact on self-esteem and may discourage participation in physical activity. We describe the experiences of CYP under the care of a tertiary weigh...

Background: Hypothalamic obesity (HO), defined as abnormal weight gain due to physical hypothalamic destruction, is characterised by significant hyperphagia. HO is not usually responsive to dietary interventions. No pharmacotherapies are specifically approved for HO and efficacy of glucagon-like peptide-1 receptor agonists (GLP-1 RA) is uncertain. Outcomes of bariatric surgery in adults with HO are variable. We describe a young person with HO and the different management strat...

Background: We aimed to evaluate first year outcomes for our Complications of Excess Weight (CEW) Service based at our tertiary paediatric centre. Children and young people with significant obesity in our region and referred to the service, receive tier 3 weight management support, including intensive lifestyle and psychosocial assistance both through clinics and in the community, including support delivered at home. Referral criteria are an age less than 16 years ay referral ...