Endocrine Abstracts

Background: Studies have shown that body mass index (BMI) thresholds for defining overweight and obesity among South Asian (SA) adults should be lower than those for White Caucasians (WC) due to increased risk of type 2 diabetes (T2D). Although children and adolescents of SA ethnicity are known to be at increased risk of insulin resistance and T2DM at lower BMI threshold, there are no guidelines to define adjusted overweight/obesity thresholds for SA children compared to WC ch...

Background: Obtaining a genetic diagnosis for obesity offers various benefits; it enables screening of associated pathology, reduces stigma by demonstrating an organic cause, and guides potential access to emerging novel medications. The number of genes recognised as causative of severe obesity has significantly increased in recent years. With obesity prevalence rising, stratifying patients for genetic testing becomes challenging. Our obesity service genetic testing pathway co...

Background: Obesity is common in young people with Duchenne Muscular Dystrophy (DMD) and may lead to abnormalities of glucose homeostasis and insulin resistance. Annual measurement of HbA1c and sex hormone binding globulin (SHBG), shown to be inversely related to insulin levels, was introduced as local clinical monitoring in 2022. This report is an audit against our local guidance and service evaluation.Methods: Based on the American Academy Paediatrics ...

Childhood obesity rates continue to rise, with 1/5 primary aged (Year 6) children now obese (NCMP 2022). Since 2023, Semaglutide, a GLP-1 receptor agonist, has been licenced for use in children with severe obesity, aged 12-18 years, with licencing allowing prescription for two years. Semaglutide acts on central satiety pathways to reduce hunger signals, reduce gastric emptying and stimulate insulin secretion.Objectives: 1) Pilot a group session for patie...

Introduction: Rates of obesity in children are rising and the cause is multifactorial. Previous studies have shown a higher prevalence of childhood obesity in areas with high socioeconomic deprivation and that the gap is increasing gap between the obesity prevalence in the most and least deprived areas. We report data on the Index of Multiple Deprivation (IMD), specific Domains of Deprivation and E-food desert index (EFDI) data for children and young people (CYP) in the compli...

Background: Children and young people (CYP) living with obesity are at increased risk of developing various physical and mental health comorbidities. Multidisciplinary (MDT) approach for the early detection and management of comorbidities is important. We report the outcomes of the first 100 patients enrolled in the tier-3 MDT Complications from Excess Weight (CEW) service.Methods: 100 new CYP (F=53) enrolled in the CEW service from March 2022-February 2...

Aim: Longitudinal study of the prevalence of sleep-disordered breathing in children with Prader-Will Syndrome (PWS) on Growth hormone (GH) therapy.Background: Growth Hormone (GH) therapy is routinely used in the management of children with Prader-Willi Syndrome (PWS) to improve growth and body composition. However, sleep disordered breathing (SDB) may be a consequence of GH use. The aim of this study was to determine the prevalence of SDB in children wit...