Endocrine Abstracts

Background and aims: European action for the Diagnosis of Early Non-clinical Type 1 diabetes For disease Interception (EDENT1FI) targets early Type 1 Diabetes (T1D) detection to reduce the risk of diabetic ketoacidosis, delay disease progression, improve long-term health outcomes and provide a ‘softer landing’ to insulin therapy. It aims to refine screening and support in early-diagnosed individuals to allow implementation in the clinical care setting.<p class="a...

Background: The challenges of caring for young children under 7 years old with type 1 diabetes are widely acknowledged. Very young children are dependent on caregivers for their diabetes care, the burden of which can have a detrimental effect on psychosocial well-being. Significant glucose variability (GV) can negatively impact early brain development and increase long-term complication risk. Use of advancing technology, specifically hybrid closed loop (HCL) systems, is recomm...

Introduction: Paediatric diabetic ketoacidosis (DKA) is a serious complication of Type 1 diabetes mellitus (T1DM), presenting significant morbidity and mortality risks. The identification of factors associated with DKA would play an important role in directing resources and efforts at effective preventive strategies.Objectives: To describe the prevalence and factors associated with DKA in patients with diabetes from April 2021-22 and April 2022-23 in Roy...

Introduction: Children and young people (CYP) are increasingly being screened and identified with early-stage type 1 diabetes (T1D). Benefits of an earlier T1D diagnosis include a reduction in diabetic ketoacidosis, hospitalisation and a ‘softer landing’ into insulin therapy. Early-stage T1D is defined by having ≥2 islet autoantibodies (IAb), categorised into stage 1 (normoglycaemia), stage 2 (dysglycaemia), and stage 3 (hyperglycaemia). CYP with a single IAb a...

Introduction: Type 1 diabetes (T1D) can begin years before clinical presentation. Screening children and young people (CYP) for T1D using islet autoantibodies (IAb) is increasingly popular, as screening reduces diabetic ketoacidosis, hospitalisation and offers access to drug therapies for delaying T1D onset. ISPAD and the INNODIA/GPPAD/FR1DA consortium have provided recommendations for monitoring early-stage T1D (defined as pre-symptomatic with ≥2 IAb). However, no UK-sp...

Introduction: Individuals with Type 1 Diabetes (T1DM) are known to be at risk of development of further autoimmune diseases. This study aimed to identify the prevalence of thyroid and adrenal autoimmunity and dysfunction in children with T1DM.Methods: A retrospective case review was conducted of all children who presented to the Royal Hospital for Children, Glasgow with newly diagnosed T1DM between 01/09/2017-01/09/2022. Data were obtained regarding thyr...

Introduction: Hybrid closed loop pumps (HCL) incorporate insulin pumps (IP) with continuous glucose monitoring (CGM). We reviewed the glycaemic control of patients with Type 1 Diabetes(T1D) cared for at the Evelina who had upgraded from basal bolus regimen or IP to HCL between October 2020 and March 2024.Method: As per standard care, patients were reviewed in clinic every 3 months and HbA1c was measured, and time in range (TIR) reviewed using CGM data.</...

Background: Type 2 diabetes mellitus (T2DM) is increasingly prevalent in children and young people due to increasing rates of obesity. The benefits of a dedicated T2DM clinic include MDT input and standardisation of patient care. The aim of this study was to evaluate current practice for management of T2DM upon initiation of the first dedicated T2DM paediatric clinic in Scotland.Methods: Retrospective review of clinical information via electronic patient...