Endocrine Abstracts

56 patients under the care of the paediatric diabetes team at Wythenshawe Hospital were identified as current Omnipod® 5 insulin pump users for Type 1 Diabetes Mellitus management in April 2024. We investigated if use of this HCL caused an increase in daily insulin requirements or an increase in BMI z-score. Time in range (TIR), total daily dose (TDD) of insulin, BMI Z-score along with total daily carbohydrate intake (CHO) and insulin boluses (TDB) during the first six mo...

18 year old male patient with GCK related monogenic diabetes. Biallelic, likely pathogenic variants identified in the GCK gene. Analysis detected two heterozygous missense variants c.693T>A p.(Asn231Lys) and c.1310C>T p.(Thr437Ile). A change on both copies of the GCK gene has been described in literature but not with this particular variant. Therefore there is a challenge in interpreting exactly what this result means. Genetic testing of both parents confirmed that one...

We initiated a ‘Non Type 1/Medically Complex Type 1’ Diabetes Clinic in a tertiary paediatric diabetes service in July 2023. Prior to this, patients were seen in the routine clinic which presented some challenges. This clinic has allowed a more focused review of patients with complex diabetes. Our current patient cohort is 25 patients. Monogenic Diabetes accounts for 12 patients with HNF1A, HNF1B, HNF4A, KCNJ11, GCK and RFX6 mutations. Other diagnoses include Wolfram...

Background: There is increasing evidence of the role of diabetes autoantibody testing in the classification of less common types of diabetes. Patients with negative autoantibodies may warrant further investigation to ensure the correct diagnosis is reached.Objectives: - To identify and characterise the population of patients <16yrs with triple autoantibody (GAD, IA2, ZnT8) negative diabetes in Lanarkshire.- To develop a new guideline for the manageme...

Objectives: In the UK, 25 - 38% of children with new onset diabetes present with diabetic ketoacidosis (DKA). The objective of this study is to describe the varying presentations of new onset diabetes and the difficulties in recognising them amongst several undifferentiated children.Methods: The characteristics of children diagnosed with new onset diabetes from January to December 2023 presenting to a single centre were studied.Res...

Objectives: The incidence of new onset diabetes in children has increased since the first year of the COVID-19 pandemic. Our objectives were to investigate the incidence of new onset diabetes in children in the post pandemic era.Methods: Single centre study in a multi ethnic prevalent population of 425 children with diabetes.Results: We observed an unusual spike in new onset paediatric diabetes during the first COVID pandemic wave....

Introduction: The transition of a young person from child to adult services should be a purposeful and planned person-centred process that starts before the formal transfer of care occurs. In chronic long-term disorders such as Diabetes, this becomes more challenging and demanding. The period of transition coincides with a critical time of biopsychosocial change for a young person as they mature from a child to young adult. It is important to ensure the transition planning is ...

Introduction: The Type 1 Diabetes and Eating Difficulties/Disorders of Eating Network (T1DDEN) Task and Finish Group: Identification and Screening was established in December 2023 as part of an over-arching workstream to tackle eating difficulties and eating disorders in paediatric diabetes care. Pursey et al., 2020, revealed a wide variety of screening tools (n = 48), but a paucity of validated screening tools(n = 5) for Type 1 Diabetes. <p clas...