Endocrine Abstracts

Background: Laos is a LMIC in South-east Asia (SEA) where health coverage does not provide for insulin and blood glucose testing. Before 2016, no person was known to have survived type 1 diabetes (T1D). Action4Diabetes (A4D) has since been providing insulin and blood glucose testing kits for Laotian patients with T1D. As the patients are now surviving and living with T1D, early detection of diabetes-related complications becomes imperative. In March 2024, a diabetic retinopath...

Background: In numerous low-income countries (LMICs) across Southeast Asia, the standard insulin therapy for people diagnosed with type 1 diabetes (T1D) is twice-daily premix insulin regimen. In Laos, the national health coverage fdoes not include provisions for insulin or blood glucose testing kits. Prior to 2016, no Laotian individuals were known to have survived with T1D. Intensive insulin therapy utilising a multiple daily insulin (MDI) regimen has now become the recommend...

Background: Transition from paediatric to adult diabetes services is a critical period influencing health outcomes. Ensuring a smooth transition process has been a significant challenge, often associated with a high rates of disengagement and DKA admissions, and clinic non-attendance once the young person is transferred to adult services.Objectives: This study aims to evaluate impact of transition readiness interventions as part of the NHS England Transi...

Intentional insulin overdose is an extremely uncommon but very significant paediatric emergency. <0.1% of all calls to the National Poisons Information Service in the U.K. over a 10-year-period related to insulin poisoning. No systematic studies or randomised controlled trials of the management of insulin poisoning exist. The available evidence consists predominantly of case reports. A a consequence there are no consensus-based guidelines for optimal management. I present ...

Background: The UK National Paediatric Diabetes Audit (NPDA) data reports disparities in Haemoglobin A1c (HbA1c) levels among children and young people (CYP) with Type 1 Diabetes (T1D), with higher levels in those of Black ethnic background and lower socioeconomic status who have less access to technology. We investigate HbA1c differences in a T1D cohort with higher than national average technology uptake where > 60% come from an ethnic minority and/or socioeconomically de...

Introduction: Hybrid closed-loop (HCL) systems improve time in range (TIR, 3.9-10.0 mmol/l) in children with type 1 diabetes (T1D). However, real-world data across different age groups is lacking.Objectives: Evaluate glucose metrics in children with T1D using HCL systems, categorised by age groups.Methods: Retrospective analysis (2019-2024) of children switching from continuous glucose monitoring (CGM) to HCL at a single tertiary c...

Confidence of Emergency Department (ED) Clinicians in the management of Paediatric Type 1 Diabetic (T1DM) Emergencies was investigated at Wythenshawe Hospital to gain an understanding of future training needs. A questionnaire assessing the overall confidence of ED clinicians in the recognition and management of Diabetic Ketoacidosis (DKA), management of children with insulin pump therapy and use of the BSPED sick day rules was circulated. Previous training on this topic in the...

Background and Aims: The Omnipod® 5 Automated Insulin Delivery (AID) System, which allows for personalised therapy through customisable glucose targets from 6.1-8.3 mmol/l in 0.55 mmol/l increments recently became commercially available for people with type 1 diabetes (T1D) aged 2 years and older in the United Kingdom (UK). This study aimed to evaluate the early real-world performance of the system in the first cohort of paediatric and young adult UK users....