Endocrine Abstracts

Background: Paediatric Quality of Life Inventory 4.0 (PedsQL) is a 23-item questionnaire completed by children and young people (CYP) and parents/carers, to measure health-related quality of life (HRQoL). It comprises four domains (Physical, Emotional, Social, School Functioning) and is scored 0-100, with higher scores indicating better HRQoL. We report baseline PedsQL scores of CYP living with severe obesity under the care of two, tier 3 Complications of Excess Wei...

Introduction: Children and adolescents with a body mass index (BMI) greater than the 98th centile are at an increased risk of complications including cardiovascular and liver disease and type 2 diabetes mellitus. Currently, lifestyle modification is the first line intervention. Pharmacotherapy, such as liraglutide and semaglutide, has recently been licensed for adolescents greater than 12 years of age. This study aimed to compare the impact of pharmacotherapy and lifestyle mod...

Introduction: Turner syndrome (TS) is a chromosomal disorder characterised by an abnormality of or a partial or complete absence of one of the X chromosomes in a phenotypic female. The TS population experience aortic dissection at a rate ten times that of the general population, for which hypertension is a modifiable risk factor. Our primary aim was to determine the frequency of hypertension in girls attending a tertiary paediatric dedicated TS clinic in the West of Scotland a...

Background and aims: A critical component of adrenal insufficiency (AI) management is education for the family and young person regarding sick day episode management. Deficits in patient education have been identified to contribute to adrenal crisis risk. The aim of this online survey distributed via the British Society for Paediatric Endocrinology (BSPED) paediatric endocrine nurse specialists (PENS) mailing list is to identify current clinical practice regarding education in...

Background: Gonadotrophin-Releasing Hormone agonists (GnRHa) are the mainstay of treatment for central precocious puberty (CPP). The long-acting formulation, Decapeptyl SR (Triptorelin pamoate), is commonly used, given as an 11.25 mg intramuscular injection 12-weekly. Recently, a 24-weekly, 22.5 mg preparation, has been introduced with reduced numbers of injections offering cost and patient benefits. Results of a two-centre UK study demonstrated no significant difference in ef...

Background: A recent case of a seven-year-old boy developing diabetes insipidus, central hypothyroidism and growth hormone deficiency following a severe traumatic brain injury (TBI) highlighted a lack of surveillance for post-TBI pituitary dysfunction within the tertiary paediatric hospital of Northern Ireland. There are limited paediatric studies into this area, but evidence suggests post-TBI hypopituitarism occurs fairly frequently in children; with prevalence of isolated ho...