Endocrine Abstracts

Objective: To evaluate whether Thyroid peroxidase antibody (anti-TPO) screening is a useful tool in the management of Congenital Hypothyroidism (CH) and determining aetiology.Background: Thyroid peroxidase (TPO) is essential for thyroid hormone synthesis catalyzing the iodination of tyrosine residues and their coupling to form T3 and T4. It is hypothesized that anti-TPO can cross the placenta, bind to TPO, inhibit its activity in the fetal thyroid gland ...

Background: Treatment modalities for childhood neuroblastoma include chemotherapy, surgery, and radiotherapy. Metaiodobenzylguanidine (mIBG) scans labelled with radioisotopes can be used for diagnosis and disease surveillance (123 I-mIBG) and treatment (131 I-mIBG) in these patients. Thyroid dysfunction following mIBG scan exposure is a documented complication and thyroid protection with potassium iodide is recommended.Aim: The audit aimed to identify th...

Introduction: Psychological and socioeconomic risk factors such as neurodiversity, learning needs and deprivation are associated with increased risk of childhood obesity. Increased socioeconomic deprivation is linked with higher psychological adversity. Improved understanding of the interaction between psychosocial risk factors and childhood obesity could change intervention approach; preventing poor adult health, deterioration of quality of life and reduced life expectancy.</...

Introduction: Differences in sex development (DSD) services now include psychology provision as standard care within MDTs. Caregivers and CYPs have wide-ranging biopsychosocial needs and care should be delivered via holistic, specialist MDTs, including access to specialist clinical psychology.Objective: Evaluate i) psychology input required for children with DSD, ii) review interventions typically accessed via specialist psychology, iii) evaluate clinici...

Aim: This study aimed to evaluate changes in growth, body composition and bone health in children and adolescents with CF following treatment with Kaftrio.Methods: Retrospective study including children with CF who had dual energy X-ray absorptiometry (DXA) prior to starting Kaftrio and after one year of therapy as part of their routine care. DXA lean mass index (LMI: defined as DXA lean mass/height2) and fat mass index (FMI: defined as DXA fa...