EYES2024 ESE Young Endocrinologists and Scientists (EYES) 2024 Diabetes, Obesity and Metabolism (13 abstracts)
Relation between autonomic symptoms and CAN risk score in type 2 diabetes: preliminary results
Boni Stefano 1,2 , Zanni Eleonora 1,2 , Coluccia Silvia 1,2 , Colzani Massimiliano 1,2 , Sueri Roberta 1,2 , Rochira Vincenzo 1,2 , Simoni Manuela 1,2 & Greco Carla 1,2
1Unit Endocrinology, Department Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; 2Unit Endocrinology, Department Medical Specialties, Modena University Hospital, Modena, Italy
Introduction: COMPASS 31 questionnaire is widely employed for screening of cardiac autonomic neuropathy (CAN) in diabetes, yet its diagnostic performance varies across studies. The aims of the study are to evaluate the relation between score of the COMPASS 31 and CAN Risk Score in type 2 diabetes (T2D); additionally, to assess its performance in diagnosing diabetic peripheral neuropathy (DPN).
Methods: The study involved 68 participants with T2D (mean age 62.53±10.82 years, duration diabetes 9.87±7.45 years, HbA1c 56.62±14.51 mmol/mol, 76,5% males), so far. All participants underwent DPN assessment, orthostatic hypotension (OH) test, and completed the COMPASS 31. DPN was defined by at least one abnormality among neuropathic symptoms (Michigan Neuropathy Screening Instrument-Q, MNSI-Q) and signs (Diabetic Neuropathy Index, DNI and Michigan Diabetic Neuropathy Score, MDNS). COMPASS 31 was analysed to obtain six domain weighted scores and a total weighted score (TWS), which was considered abnormal if >16.44. CAN risk score was calculated.
Results: In the total cohort, 45.6% of significant TWS of COMPASS 31 and 37.5% of high CAN risk score have been detected. Moreover, DPN prevalence was 42.6%. The TWS was similar in subjects with low and high CAN risk score (15.84±11.19 vs 18.32±11.71.83; P 0.648). Considering domains separately, patients at high risk for CAN showed greater impairment in the vasomotor domain (0.29±0.74 vs 0.62±1.16; P 0.005) and strongly correlation with secretomotor domain (rho=0.252, P = 0.044); no differences in the weighted scores of the other domains were found. No correlations between TWS and value of OH and CAN risk score were observed. On the other hand, correlations between MNSI-Q and TWS (rho=0.356, P = 0.033) and MNSI-Q and vasomotor domain (rho=0.90, P = 0.001) have been observed.ConclusionIn these preliminary results, COMPASS 31 exhibits a scarce association with CAN Risk Score in T2D. In contrast, a fair correlation with clinical DPN was observed.
Volume 102
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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