EYES2024 ESE Young Endocrinologists and Scientists (EYES) 2024 Reproductive Endocrinology (10 abstracts)
Previous illicit androgen users display persistently impaired Leydig cell capacity but recovered luteinising hormone secretion
Yeliz Bulut 1,2 , Niels Brandt-Jacobsen 1,3 , Rasmus Madsen 1,2 , Jan Frystyk 4,5 , Jakob Albrethsen 6 , Niels Jørgensen 6 , Anders Juul 2,6 , Caroline Kistorp 1,2 & Jon Jarløv Rasmussen 1
1Department of Nephrology and Endocrinology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark; 2Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Denmark, Copenhagen, Denmark; 3Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark; 4Department of Endocrinology, Odense University Hospital, Odense, Denmark; 5Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark; 6Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark
Background: A general finding among previous illicit androgen male users is persistently lower serum testosterone than nonusers and may be caused by reduced pituitary luteinising hormone (LH) secretion. However, the functional capacity of the testes and pituitary remains to be assessed after androgen use. We compared pituitary-testis-axis capacity in previous illicit androgen users and nonusers.
Methods: We conducted a cross-sectional study including men involved in recreational strength training with and without a history of androgen use. We performed gonadotropin-releasing hormone (GnRH) and human chorionic gonadotropin (hCG) stimulation tests to assess pituitary function and testicular Leydig cell capacity. Serum total testosterone and insulin-like Factor 3 (INSL3) were measured using LC-MS/MS. Sexual function was evaluated by the IIEF-15 questionnaire.
Results: We compared 30 previous users with elapsed duration since androgen cessation, geometric mean (95% CI), 2.0 (1.2;3.5) years and 30 nonusers. Mean (SD) age of all participants was 38 (8) years. The mean (95%CI) increase in testosterone following hCG injection was lower among previous users than nonusers; group difference: -9·4 (95% CI) (-13·6;-5·2) nmol/l, P < 0·001. We found no differences in LH secretion between groups. In linear regression models using erectile function as dependent variable, higher Leydig cell capacity, expressed as either a serum testosterone increase during the hCG test (P = 0·043) or INSL3 (P = 0·008), was independently associated with better erectile function, whereas baseline serum testosterone was not (P = 0·861).
Conclusion: Previous illicit androgen users presented a persistently decreased Leydig cell capacity but normal pituitary function two years after androgen cessation
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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