EYES2024 ESE Young Endocrinologists and Scientists (EYES) 2024 Calcium and Bone (9 abstracts)
Unraveling the puzzle of bone health in Klinefelter syndrome: association between dxa derived bone quality indexes and body composition parameters in a single center cohort
Stella Pigni 1,2 , Walter Vena 1,3 , Maria Francesca Birtolo 1,2 , Fabio Massimo Ulivieri 4 , Luca Rinaudo 5 , Antonio Carlo Bossi 3 , Alessandro Pizzocaro 2 , Andrea Lania 1,2 & Gherardo Mazziotti 1,2
1Humanitas University, Department of Biomedical Sciences, Pieve Emanuele, Milano, Italy; 2IRCCS Humanitas Research Hospital, Endocrinology, Diabetology and Medical Andrology Unit, Rozzano, MI; 3Diabetes Center, Humanitas Gavazzeni Institute, 24125 Bergamo, Italy; 4Casa di Cura la Madonnina, Milano, Italy; 5Tecnologie Avanzate Srl, Turin, Italy
Introduction: Bone mineral density (BMD) lacks sensitivity in individual fracture risk assessment in patients with Klinefelter syndrome (KS), independently of testosterone replacement therapy (TRT). Thus, new dual-energy X-ray absorptiometry (DXA) derived diagnostic tools are needed.
Methods: Trabecular bone score (TBS), bone strain index (BSI) and total body DXA parameters of bone geometry and body composition were evaluated in a single center cohort of men with KS.
Results: 44 males with 47, XXY KS were enrolled, with median age 39.5 years (range 18-61). 39/44 (88.6%) patients were receiving TRT, with a median treatment duration of 6.5 years (range 1-37). Median body mass index was 25.4 kg/m2 (range 17.3-40). Low BMD was found in 7/44 (15.9%) patients. Correlation analysis showed that fat mass index (FMI: r 0.64, P < 0.001), fat-to-lean mass index ratio (FMI/lMI: r 0.66, P < 0.001) and visceral fat mass (r 0.56, P < 0.001) were significantly associated with lumbar BSI. Interestingly, a strong correlation of TBS with lumbar BSI (r -0.73, P < 0.001) was also observed.
Conclusion: These single cohort results suggest a possible role of higher body fat indexes as determinants of lower bone quality in adults with KS. Large-scale prospective cohort studies are needed to investigate the predictive value of body composition parameters on fracture risk in KS patients.
Volume 102
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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