Endocrine Abstracts

Introduction: Despite their benign character, craniopharyngiomas tend to have an unpredictable evolution even after surgical treatment, while the onset of surgery-related growth hormone deficiency is frequently noted. As a part of the multihormonal process that promotes linear growth in GH-deficient children, other mechanisms (like hyperinsulinemia, hyperleptinemia, hyperprolactinemia, hypoestrogenism, low levels of IGF binding protein and possible GH variants) may be involved...

Introduction: One of the most common referrals to a general endocrine clinic is hyperprolactinemia. It’s very difficult to differentiate between stress induced hyperprolactinaemia and true hyperprolactinaemia and may result in unnecessary endocrinology appointments and imaging.Methods: We have collected data for 60 patients who had a cannulated prolactin test between January 2017 and April 2024 in the Royal United Hospital of Bath (RUH). After cannu...

Introduction: Langerhans cell histiocytosis (LCH) is a multi-organ disease characterized by clonal proliferation of immature dendritic cells. Isolated hypothalamo-pituitary (HP-LCH) involvement is rare and the coexistence of empty sella syndrome (ESS) is even rarer. We report a case of LCH with ESS and adipsia presenting as life-threatening hypernatremia.Case presentation: A previously healthy 26-year-old woman presented with amenorrhea, headaches, somno...

Acromegaly is a rare disease caused by the presence of a sporadic growth hormone (GH)-secreting pituitary/neuroendocrine adenoma. Patients with acromegaly progressively go through disfigurement of somatic features and relevant systemic manifestations, induced by chronic exposure to growth hormone. In this context of multimorbidity, it is also necessary to assess the cognitive and neuropsychological picture, which is often compromised. In order to perform a comprehensive assess...

Efnb2 plays an integral role during mouse development and in the adult stem cell niche. Efnb2 does encode for Ephrinb2 ligand which then binds to Eph receptor. Preliminary data suggest implication of Efnb2 in pituitary tumours and during normal pituitary embryogenesis. Currently, involvement of Eph:Ephrin signalling pathway in pituitary development is unknown. Better knowledge of Efnb2 in the pituitary will help to improve understanding of endocrine diseases. Deletion of Efnb2...

Introduction: Mitochondrial encephalopathy, lactic acidosis and stroke like episodes (MELAS) is one of the most studied and described mitochondrial disorder. However, the markedly variable presentation, particularly among paediatric patients makes diagnosis challenging. Here, we report an unusual manifestation of MELAS in a patient evaluated for short stature with growth hormone deficiency.Case presentation: A 15 years old female, born out of non- consan...

Multiple pituitary hormone deficiency (MPHD) associates variable misleading hypothalamic-pituitary imaging (MRI) aspects, with unpredictable dynamics until puberty, which requires a differential diagnosis with acquired pituitary changes that can modify subsequent case management. The patient, aged 7 years and 4 months, with no significant personal or hereditary antecedents, presented at the age of 5 years and 7 months to the Iasi Endocrinology Clinic for severe short stature (...