Endocrine Abstracts

Introduction: Thyroid nodules discovered during pre-transplant evaluation may delay the transplantation process. While studies suggest an increased incidence of thyroid cancer following solid organ transplantation, the impact on prognosis in papillary thyroid cancer (PTC) among renal transplant recipients remains unclear.Methods: We conducted a retrospective review of renal transplant recipients with a history of PTC at our institution between 1998 and 2...

Introduction: Increased GH and IGF-1 levels in acromegaly results in several micro and macrovascular changes. There are controversial results about the effects of GH/IGF-1 on retinal vasculature. Gremlin-1 is a BMP-4 antagonist which binds to VEGFR to activate its pathway and has demonstrated angiogenic properties on several tissues. We aimed to detect retinal changes in acromegaly and examine its association with serum gremlin-1 levels.Methods: We inclu...

Introduction: McCune-Albright syndrome (MAS) is a rare genetic disorder caused by somatic gain-of-function mutations in the GNAS gene, leading to persistent activation of the stimulatory alpha subunit of the G protein cellular signaling complex and dysregulated cyclic AMP production in the target tissues. The phenotype, although highly variable, is classically defined as the triad of fibrous dysplasia of the bone, cafe-au-lait skin macules and hyperfunctioning endocrinopathies...

Introduction: Hypoparathyroidism with abnormal calcium deposits in the basal ganglia is known as Fahr’s syndrome, a rare condition affecting fewer than 1 in 1,000,000 people, typically those aged 40-60. In contrast, Fahr’s disease is characterized by isolated brain calcification without underlying metabolic or endocrine disorders. Both conditions often manifest with neurological and cognitive disorders, seizures, and sometimes psychosis. However, symptoms of Fahr&#14...

Introduction: Glucocorticoids (GCs) are closely related to cortisol and the dysregulation of its secretion can lead to the onset of disorders. Cushing’s syndrome (CS) is the clinical manifestation of hypercortisolism and can also develop in subjects who voluntarily or accidentally take high GCs doses. The aim of this study is to conduct preliminary investigations to characterize the HEK293 cell line, to evaluate its response to GCs and to compounds with GC-like activity.<...

Introduction: Autoimmune polyendocrine syndrome type 2 (APS-II) is characterized by the presence of at least two of the following autoimmune disorders: Addison’s disease, and autoimmune thyroid disease or diabetes mellitus. It is the most prevalent form of autoimmune polyendocrine syndrome and can be accompanied by other autoimmune disorders, leading to a range of clinical pictures. Case description: We present the case of a 57-year-old woman with a...