Endocrine Abstracts

Introduction: COMPASS 31 questionnaire is widely employed for screening of cardiac autonomic neuropathy (CAN) in diabetes, yet its diagnostic performance varies across studies. The aims of the study are to evaluate the relation between score of the COMPASS 31 and CAN Risk Score in type 2 diabetes (T2D); additionally, to assess its performance in diagnosing diabetic peripheral neuropathy (DPN).Methods: The study involved 68 participants with T2D (mean age...

Background: Hepatic steatosis and diabetic peripheral neuropathy (DPN) share etiological and clinical correlates, while relationship between liver fibrosis and DPN has not been well investigated. AIMS. To evaluate the association between liver fibrosis and DPN and investigate the non-invasive scores of fibrosis as predictors of DPN.Methods: Observational, cross-sectional study including individuals with type 2 diabetes (T2D) and steatosis. Neurological a...

Introduction: Type 1 diabetes mellitus (T1DM) is an autoimmune disease primarily characterized by the destruction of pancreatic beta cells, leading to deficiencies in insulin production. The development of T1DM is attributed to a combination of environmental, immunological, metabolic, and epigenetic factors. The aim of this study is to analyze the expression profile of circulating miRNAs in T1DM patients to establish differences based on the time of diagnosis, whether in adult...

Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a common comorbidity of obesity. In this study, we sought to determine hepatic metabolic and mitochondrial effects of the Glucagon-like Peptide-1-agonist semaglutide, the sodium-glucose linked transporter 2-inhibitor empagliflozin and Peptide YY3-36 in diet-induced obese rats with additional chronic inhibition of nitric oxide synthase via Nω-nitro-L-arginine methyl ester (L-NAME), to induce ...

Introduction: Clinically significant hypoglycaemia, defined by blood glucose levels below 3 mmol/l (level 2) or requiring third-party assistance (level 3), poses significant risks for individuals with diabetes. However, limited information exists regarding their characteristics, management, and outcomes. The objective was to explore the characteristics, precipitating factors, and outcomes of individuals admitted with level 2 or 3 hypoglycaemia.Methods: T...

Introduction: Diabetic macular edema (DME) is one of the leading causes of visual impairment in individuals with diabetes. In type 1 diabetes (T1D), DME is often a late-stage complication of diabetic retinopathy (DR). However, literature remains scarce regarding risk factors for DME, particularly its relationship with glycemic control assessed by continuous glucose monitoring (CGM). Methods: We conducted a retrospective cohort study of adult T1D patients...

Background and aims: Leukocyte telomere length (LTL) is considered as a promising prognostic marker associated with COVID-19 severity, adverse outcomes (hospital admission, need for critical care, respiratory support), and mortality. However, LTL contribution to long COVID development is unclear. In this study, we aimed to evaluate the relationship between LTL and long COVID development in type 2 diabetes patients (T2D) concerning clinical phenotype, gender, and biological age...

Introduction: In 2021, a new recommendation was put forward by the Joint British Diabetes Society-Inpatient (JBDS-IP) group to reduce fixed rate intravenous insulin infusion (FRIII) from 0.1 to 0.05 units/kg/hour when blood glucose falls <14 mmol/l in the management of Diabetic Ketoacidosis (DKA). This helped reduce the risk of associated complications. However, there has not been any evidence on whether this has been appropriately implemented. Metho...

Introduction: Familial partial lipodistrophy (FPL) is a rare genetic disorder characterized by a progressive loss of adipose tissue from various areas of the body. Associated complications include diabetes mellitus, hypertriglyceridemia, non-alcoholic fatty liver disease, polycystic ovaries, acanthosis nigricans, premature atherosclerosis.Case presentation: The first case is about a 19-years-old woman, known with insulinoresistance (under metformin) and ...

Introduction: Post-COVID-19 syndrome (PCS; long COVID-19, post-acute COVID-19, long-term effects of COVID-19) is an emerging health problem in people recovering from COVID-19 infection within the past 3-6 months. The study of COVID-19 severity markers and the assessment of PCS prognosis have encouraged the discovery of the molecular mechanisms responsible for PCS and inevitable pathological conditions. Aim: to define the links between mitochondrial (mt)-DNA levels in blood leu...

Introduction: Anemia is one of the important complications of diabetes mellitus (DM), adversely affecting the progression and development of other diabetes-related complications. Despite this, little information is available on the prevalence of anemia and its associated factors in type 2 diabetes mellitus (T2DM). These associated factors are older age, worsening renal function, cardiovascular disease (stroke or ischemic heart disease), peripheral vascular disease, longer dura...

Introduction: Diabetic striatopathy (DS) is a rare and potentially fatal complication observed in individuals with uncontrolled hyperglycemia. Its prevalence, estimated at less than 1 in 100,000, underrepresents its true incidence, owing to the lack of knowledge about it in physicians. The highest prevalence was seen in Asia (71.6%), Europe (8.5%), and America (4%). Older Asian women were more affected, however, 6 cases were reported in pediatric patients.<p class="abstext...

Introduction: A strong association exists between obesity and heart failure with preserved ejection fraction (HFpEF). Obesity, usually induced by a high-fructose/high-fat Western diet, is one of the main causes of HFpEF. Here, we compare the cardiac and metabolic effects of different diets in combination with the NO-synthase inhibitor L-NAME (LN) in male Wistar rats. Methods: Male Wistar rats were randomized into the following groups (n = 6, all...