Calcium and Bone

ea010247 | Calcium and Bone | EYES2024

A case report of severe osteomalacia in a young adult female - in search of a FGF23 secreting tumor

Popescu Diana-Ioana , Marcela Neculăeş Ginuţa , Stafie Ilona-Beatrice , Luca Celina , Leuştean Letiţia , Bilhă Ştefana , Preda Cristina , Ungureanu Maria Christina

Introduction: Tumor-induced osteomalacia (TIO), is a rare paraneoplastic syndrome caused by mesenchymal tumors which are typically benign, small and slow-growing. They express and secrete fibroblast growth factor 23 (FGF23), leading to decreased reabsorption of phosphate and production of 1,25-dihydroxyvitamin D by the kidney. The resulting hypophosphatemia causes osteomalacia, bone pain, muscle weakness, and fractures.Case presentation: This is the case...

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ea010270 | Calcium and Bone | EYES2024

Bone-active drugs in pre-menopausal women with breast cancer undergoing hormone deprivation therapies

Birtolo Maria Francesca , Pedersini Rebecca , Palermo Andrea , Vena Walter , Morenghi Emanuela , Cristofolini Giacomo , Presciuttini Barbara , Tabacco Gaia , Naciu Anda Mihaela , Pigni Stella , Lagana Marta , Mazzoleni Federica , Cosentini Deborah , Ciafardini Antea , Pagani Mauro , Farina Davide , Balzarini Luca , Zambelli Alberto , Torrisi Rosalba , Cianferotti Luisella , Napoli Nicola , Carlo Bossi Antonio , Lania Andrea Gerardo , Berruti Alfredo , Mazziotti Gherardo

Background: Bone health management in pre-menopausal women with breast cancer (BC) under hormone-deprivation therapies (HDTs) is often challenging, and the effectiveness of bone-active drugs is still unknown. Methods: This retrospective multicenter study included 306 premenopausal women with early BC undergoing HDTs. Bone mineral density (BMD) and morphometric vertebral fractures (VFs) were assessed 12 months after HDTs initiation and then after at least...

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ea010267 | Calcium and Bone | EYES2024

Abstract withdrawn...

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ea010234 | Calcium and Bone | EYES2024

Male osteoporosis, a still overlooked and undermanaged issue: an identikit of patients seeking bone health evaluation at a tertiary academic medical centre

Maria Demichelis Veronica , De Vincentis Sara , D'Angelo Giulia , Taliani Erica , Ansaloni Anna , Domenici Daniela , Madeo Bruno , Rochira Vincenzo

Introduction: Male osteoporosis is undermanaged. The aim of this study was to characterize from real-life data male patients seeking the first bone health evaluation at a tertiary academic medical center, over a 14-year observation period. Methods: Retrospective, cross-sectional study, including adult men referring to our Center from 2007 to 2021 for bone health evaluation. Comorbidities and history of fragility fractures were investigated. Osteoporosis ...

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ea0102149 | Calcium and Bone | EYES2024

Bone suffering in ‘tertiary’ hyperparathyroidism - from generalized brown tumors to hungry bone syndrome

Ilic Sasa , Dimitrijevic Sreckovic Vesna , Milic Gordana , Gostiljac Drasko , Ristic Masa , Rovcanin Branislav , Stojkovic Mirjana , Miljic Dragana

Introduction: Tertiary hyperparathyroidism (tHPT) develops when the parathyroid gland becomes autonomous in hormone secretion, usually after prolonged secondary hyperparathyroidism. "Brown tumours" (BT) and postoperatively hungry bone syndrome (HBS) are rare complications of HPT occurring in up to 1.5% in tHPT and around 13% in primary HPT, respectively.Case presentation: A 49-year-old female patient was referred to an endocrinologist...

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ea0102164 | Calcium and Bone | EYES2024

Bone mineral density in multiple endocrine neoplasia ten years after primary parathyroidectomy

Kuusela Emma , Kostiainen Iiro , Ritvonen Elina , Ryhanen Eeva M. , Schalin-Jantti Camilla

Introduction: Primary hyperparathyroidism (PHPT) associated with multiple endocrine neoplasia type 1 (MEN1) impairs bone mineral density and causes ostoporosis already in young patients. We aimed to investigate BMD in a contemporary cohort of patients with MEN1-related PHPT after long term follow-up and compare these results to that of healthy controls.Methods: Thirty-five patients with genetically confirmed MEN1 were diagnosed with MEN1 at mean age 28.7...

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ea01029 | Calcium and Bone | EYES2024

Severe osteoporosis in young vegan women with cerebral palsy – a case report

Meliš Petra , Matijaca Ana , Marušić Srećko

Introduction: Osteoporosis is a health problem that causes low bone density and quality. Additionally, a high fracture risk is linked with osteoporosis. While it is most commonly associated with postmenopausal women and the elderly, it can also impact individuals with early-onset physical limitations such as cerebral palsy (CP). This study highlights the challenges of managing osteoporosis in a young women with CP.Case presentation: A 38-year-old woman p...

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ea0102157 | Calcium and Bone | EYES2024

Associations between serum adipokines and osteoporosis in postmenopausal women: a systematic review

Mihai Gabriela , Pop Raluca-Monica , Maria Pascanu Ionela , Ildiko Gasparik Andrea , Reginster Jean-Yves , Bruyere Olivier , Beaudart Charlotte

Introduction: The relationship between adipokines and bone mineral density (BMD) is unclear, with conflicting results. Objectives: This study aimed to determine if adipokine levels differ between postmenopausal women with osteoporosis and healthy postmenopausal women, and if these levels are associated with low BMD. The adipokines studied included adiponectin, leptin, resistin, visfatin, vaspin, chemerin, omentin-1, retinol binding protein 4 (RBP-4), CTR...

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ea0102114 | Calcium and Bone | EYES2024

Unraveling the puzzle of bone health in Klinefelter syndrome: association between dxa derived bone quality indexes and body composition parameters in a single center cohort

Pigni Stella , Vena Walter , Francesca Birtolo Maria , Massimo Ulivieri Fabio , Rinaudo Luca , Carlo Bossi Antonio , Pizzocaro Alessandro , Lania Andrea , Mazziotti Gherardo

Introduction: Bone mineral density (BMD) lacks sensitivity in individual fracture risk assessment in patients with Klinefelter syndrome (KS), independently of testosterone replacement therapy (TRT). Thus, new dual-energy X-ray absorptiometry (DXA) derived diagnostic tools are needed.Methods: Trabecular bone score (TBS), bone strain index (BSI) and total body DXA parameters of bone geometry and body composition were evaluated in a single center cohort of ...

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Endocrine Abstracts

ESE Young Endocrinologists and Scientists (EYES) 2024

ESE Young Endocrinologists and Scientists (EYES) 2024

A case report of severe osteomalacia in a young adult female - in search of a FGF23 secreting tumor

Bone-active drugs in pre-menopausal women with breast cancer undergoing hormone deprivation therapies

Male osteoporosis, a still overlooked and undermanaged issue: an identikit of patients seeking bone health evaluation at a tertiary academic medical centre

Bone suffering in ‘tertiary’ hyperparathyroidism - from generalized brown tumors to hungry bone syndrome

Bone mineral density in multiple endocrine neoplasia ten years after primary parathyroidectomy

Severe osteoporosis in young vegan women with cerebral palsy – a case report

Associations between serum adipokines and osteoporosis in postmenopausal women: a systematic review

Unraveling the puzzle of bone health in Klinefelter syndrome: association between dxa derived bone quality indexes and body composition parameters in a single center cohort

BiosciAbstracts