ETA2024 Poster Presentations Treatment – surgery (10 abstracts)
1Karolinska University Hospital, Department of Endocrinology Karolinska University Hospital, Stockholm, Sweden; 2Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden, Department of Endocrinology Karolinska University Hospital, Stockholm, Sweden; 3Karolinska Institutet, Department of Endocrinology, Department of Endocrinology Karolinska University Hospital, Stockholm, Sweden
Purpose: Preoperative iodine therapy due to toxic nodular goiter (TNG) is discouraged as iodine may cause an aggravation of hyperthyroidism. We aimed to examine the effects of a short course of Lugols solution on thyroid hormones and quality of life in TNG patients.
Methods: 20 patients with TNG and subclinical to mild hyperthyroidism (free T4 <30 pmol/l) without complicating illness were included in this pre-post intervention study. All participants received Lugols solution 5 %, Three oral drops thrice daily for ten days. Heart rate, TSH, free T4, and free T3 concentrations were collected before (day 0) and after treatment (day 10). Thyroid hormones measurements were repeated at two time points during the intervention to discover any exacerbations of hyperthyroidism. ThyPRO39, a thyroid specific quality-of-life questionnaire was filled out day 0 and repeated at day 10. Differences in heart rate, thyroid hormone concentrations, and quality-of-life before and after treatment were compared.
Results: Median age was 63.5 years with a female to male ratio 19:1. Free T4 and freeT3 concentrations decreased and TSH concentration increased after 10 days of treatment. There was no difference in heart rate. No exacerbations of hormone levels were noticed in any of the participants during the intervention. Three of the 14 scales in ThyPRO39 were improved, including hyperthyroid symptoms. The remaining scales were unchanged.
Conclusion: In this pre-post intervention study on toxic nodular thyroid disease, we found that a short course of Lugols solution improved thyroid hormone concentrations and reduced hyperthyroid symptoms. This indicates that Lugols solution might be used as preoperative treatment in toxic nodular goiter.