ETA2024 Poster Presentations Hypothyroidism (10 abstracts)
Autoimmune hypothyroidism incidence in a large population-based study in northeastern italy
Simona Censi 1 , Laura Salmaso 2 , Fiammetta Battheu 3 , Ilaria Piva 4 , Cristina Clausi 5 , Giulia Messina 6 , Filippo Ceccato 7 , Ugo Fedeli 2 , Mario Saia 2 & Caterina Mian 8
1Endocrinology Unit, Department of Medicine (Dimed), University of Padua, Padua, Italy; 2Clinical Governance Unit, Azienda Zero, Veneto Region, Italy; 3University of Padua, Endocrinology Unit, Department of Medicine (Dimed), University of Padua, Uoc Endocrinologia, Padua, Italy; 4Endocrinology Unit, Department of Medicine (Dimed), University of Padua, Italy; 5Endocrinology Unit, Department of Medicine (Dimed), University of Padua, Endocrinology Unit, Padua University, Department of Medicine, Padua, Italy; 6Endocrinology Unit, Department of Medicine (Dimed), University of Padua, Padua, Endocrinology Unit, Department of Medicine (Dimed), University of Padua, Endocrinology Unit, Padua University, Department of Medicine, Padua, Italy; 7Department of Medicine (Dimed), Endocrinology Unit, University of Padova; 8Operative Unit of Endocrinology, Department of Medicine (Dimed), Endocrinology Unit, University of Padua, Padua, Department of Medicine, Padova, Italy
Objectives: An improvement in iodine status in Veneto region has been documented in the last decade. We aimed at estimating the incidence of autoimmune hypotiroidism (AH) in the Veneto Region over the period 2013-2022.
Methods: Retrospective population-based study conducted in Veneto (4.9 million people) using the population registry, an administrative health database. Between 2012 and 2022, AH incidence was defined thank to a health-care co-payment exemption for AH or any hospital diagnosis of AH. Incident AH was defined from 2013 to 2022 to exclude prevalent cases. Standardized incidence rates (IRs) were reported by age, and sex and reported for 10,000 person-years.
Results: We identified 65,397 incident cases (IR of 13.38, IC: 13.27-13.48). The female-to male incidence ratio reached a peak in the 30–34 years age group (9.78) and a nadir in the 80–84 years age group (1.35). Overall, IR decreased from 15.86 (95% CI: 15.50, 16.21) in 2013 to 12.35 (95% CI: 12.04, 12.67) in 2022, but the reduction was significant only in females. Indeed, in females IR went from 27.26 in 2013 to 20.49 in 2022 (P < 0.01), vs a decrease in males from 4.35 in 2013 to 4.27 in 2022 (P = 0.9). AH IR decrease regarded especially pre-menopausal women, with a decrease in females <55 years from 37.86 (95% CI: 36.79, 38.94) in 2013 to 27.40 (95% CI: 26.44, 28.36) in 2022 (P < 0,001), vs a weaker decrease over 55 years of age, from 20.06 (95% CI: 19.13-20.99) in 2013 to 16.56 (95% CI: 15.78, 17.35) in 2022 (P = 0.03). In 2020, an out-of-trend decrease in AH incidence was documented, corresponding to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic outbreak, with a realignment to the trend in the subsequent years.
Conclusions: We documented a decline in the incidence of AH in Veneto Region, but limited to females and especially in pre-menopausal women. These results could be related to the improvement of the iodine status in Veneto Region, thanks to a long and sustained iodine prophylaxis campaign. However, it seems clear that iodine supplementation effect on AH has been different according to sex and exposition to estrogens. SARS-CoV-2 pandemic and vaccination campaign did not change the declining trend of AH incidence.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more