Thyroid cancer associated with hashimoto thyroidits : pronostic outcomes

Trabelsi Wejdan Mohamed; Amani Hachicha; Hamdi Chouchane; Nesrine Sallemi; Houneida Boussaffa; Senda Turki

doi:10.1530/endoabs.101.PS3-23-09

PS3-23-09

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Endocrine Abstracts (2024) 101 PS3-23-09 | DOI: 10.1530/endoabs.101.PS3-23-09

ETA2024 Poster Presentations Clinical thyroid cancer research-3 (10 abstracts)

Thyroid cancer associated with hashimoto thyroidits : pronostic outcomes

Wejdan Mohamed Trabelsi ¹ , Amani Hachicha ² , Hamdi Chouchane ³ , Nesrine Sallemi ³ , Houneida Boussaffa ³ & Senda Turki ³

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¹Salah Azaiez Institut, Ent, Tunis, Tunisia; ²Fsi Hospital, Fsi, Ent, Tunis, Tunisia; ³Fsi Hospital, Ent, Ent, Tunis, Tunisia

Aim: The aim of our study was to examine the association between lymphocytic thyroiditis and papillary thyroid carcinoma.

Materials and methods: It was a retrospective covering patients who had total thyroidectomy on papillary carcinoma, between 2012 and 2023.

Results: Our study involved 24 patients with a median age of 50.17 years [31-73], predominantly female and a sex ratio of 0.6. Preoperative fine needle aspiration was performed in 10 (41.6%) patients and found Bethesda 6 in 3, Bethesda 5 in 4 and Bethesda 4 in 3. All our patients underwent surgery. Loboisthmectomy or total thyroidectomy was recommended on the basis of extemporaneous examination. The final anatomopathological examination showed papillary carcinoma in all patients, associated with lymphocytic thyroiditis in 8 (33.3%). The tumor was classified as pT1a in 25% of cases, pT1b in 25% of cases, pT2 in 29.2% of cases and pT3a in 20.8% of cases, with lymph node status pN0 in 15 patients, pN1a in 6 patients and pN1b in 3 patients. In patients with lymphocytic thyroiditis, 3 patients had capsular invasion, 2 patients vascular emboli, 4 patients had pN0 lymph node status, 3 patients pN1a and 1 patient pN1b. None of these factors was associated with lymphocytic thyroiditis according to Fisher’s exact test with a P> 0.05.

Conclusion: The link between autoimmune lymphocytic thyroiditis and papillary carcinoma is a controversial topic in the literature. Some studies have considered thyroiditis to be a protective factor against papillary carcinoma progression.