Endocrine Abstracts

Background: Non-thyroid metastases to the thyroid (NTMs) are rare, representing approximately 1.4%-3% of cases among malignant thyroid tumors.

Methods: A research of anatomopathological and cytological reports was carried out, from the years 2008 to 2023 of patients with NTMs, previously carried out in the Department of Pathological Anatomy at a tertiary hospital. Only two patients were found. Aims: we describe the clinical presentation, the demographic profile, the prognosis and the forms of treatment of NTMs.Case reportsWe describe two cases of secondary neoplastic involvement of the thyroid. The first case, female, 82 years old, history of primary hypothyroidism, systemic arterial hypertension, type 2 diabetes mellitus, breast cancer treated with mastectomy 39 years ago, as well as left nephrectomy for clear cell renal carcinoma 28 years ago. During oncological follow-up, she presented metastases to the pancreatic stump, supraclavicular lymph node on the left, as well as the appearance of two thyroid nodules on the left in a cervical ultrasound examination, classified as TIRADS-3. Thyroid aspiration puncture (FNA) was performed, suggesting secondary involvement due to renal neoplasia. The second case, male, 59 years old, diabetic and smoker for 80 pack years, diagnosed with supraglottis squamous cell carcinoma 4 years ago, treated with cordectomy, already with multiple metastatic pulmonary foci, presented 3 years after diagnosis with complaints of hoarseness and cervical bulging due to large thyroid nodule on the right shown on computed tomography, whose FNA showed poorly differentiated carcinoma with a basaloid pattern.

Conclusion: the appearance of thyroid nodules in patients with a history of malignant neoplasms should prompt investigation of a possible metastatic focus, aiming to reduce the morbidity and mortality that accompanies the underlying disease.