ETA2024 Poster Presentations Translational thyroid cancer research-1 (10 abstracts)
How (respiratory) air can complement the diagnosis of thyroid changes - a pilot study using ion mobility spectrometry
Damiano Librizzi 1 , Maike Bullmann 2 , Andreas Rembert Koczulla 3 , Markus Luster 4 , Friederike Eilsberger 5 , Andreas Pfestroff 6 , Wadim Bowl 7 , Vogelmeier Claus Franz 8 , Behrooz Hooshyar Yousefi 1 & Tobias Böselt 9
1Philipps University of Marburg, Department of Nuclear Medicine, Marburg, Germany; 2Philipps University of Marburg, Klinik für Innere Medizin, Sp Pneumologie, Marburg, Germany; 3Universitätsklinikum Gießen und Marb, Klinik für Innere Medizin, Schwerpunkt, Pneumologie, Marburg, Germany; 4University Hospital Marburg, University Hospital Marburg, Department of Nuclear Medicine, Marburg, Germany; 5University Hospital Marburg, Nuclear Medicine, Marburg, Germany; 6Universitätsklinikum Marburg, Klinik für Nuklearmedizin, University Hospital Marburg, Nuclear Medicine, Marburg, Germany, Marburg, Germany; 7Philipps University of Marburg, Department of Nuclear Medicine; 8Internal Medicine – Pneumology and Critical Care Medicine, German Center for Lung Research; 9Philipps-Universität Marburg, Klinik für Innere Medizin, Sp Pneumologie, Marburg, Germany
The aim of this pilot study is to establish a technique that can be used to detect thyroid abnormalities at an early stage, to assess the severity of these changes and to determine whether it can be used as an adjunct to other commonly used tools such as sonography, scintigraphy, fine needle aspiration biopsy and surgery. The study included 39 subjects with no identifiable thyroid changes and 86 subjects (patients) with sonographic and/or laboratory abnormalities. In the patients with thyroid changes, a histological report was available after the assessment. Only subjects > 18 years, able to give informed consent and with good expiratory capacity were included in the pilot study. Potential subjects with inflammatory processes and elevated CRP, previous malignant disease, and poor general health (ECOG 1 or higher) were excluded. Subjects were not allowed to eat or chew gum for two hours prior to measurement. A 500 ml sample for ion mobility spectrometry (IMS) with an upstream multicapillary gas chromatography (MCC) column was used to collect the exhaled air and measure the metabolites, the "volatile organic compounds" (VOCs). The last 10 ml were used for MCC-IMS and analysed after histopathological findings were available. Thyroid cancer was diagnosed in 15 people and benign findings were found in 71 people. According to the different number of cases per group, the group size was randomly adjusted to 15 cases and subgroups (control, benign and malignant groups) were formed. After evaluation, at least two peaks could be identified to differentiate these subgroups (malignant vs benign) and interestingly show a sensitivity of almost 100% and a specificity of up to 87%. The determination of VOCs in MCC-IMS seems to be a promising diagnostic procedure in the context of thyroid abnormalities for the assessment of dignity (benign vs. malignant) and thus represents an excellent and complementary investigational tool.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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