Sporadic medullary thyroid carcinoma: about 17 cases

Rim Braham; Ameni Amri; Jihene Gharsalli; Mohamed Dhaha; Souhail Jbali; Sawsen Dhembri; Skander Kedous

doi:10.1530/endoabs.101.PS2-13-04

PS2-13-04

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Endocrine Abstracts (2024) 101 PS2-13-04 | DOI: 10.1530/endoabs.101.PS2-13-04

ETA2024 Poster Presentations Medullary thyroid cancer-2 (10 abstracts)

Sporadic medullary thyroid carcinoma: about 17 cases

Rim Braham , Ameni Amri , Jihene Gharsalli , Mohamed Dhaha , Souhail Jbali , Sawsen Dhembri & Skander Kedous

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Salah Azaiez Institute, Ent, Carcinologic Head & Neck Surgery, Tunisia

Purpose: To Study the clinical, paraclinical and therapeutic features of medullary thyroid carcinomas (MTCs)

Methods: Retrospective study of 17 patients treated for MTC over a period of 6 years [2016-2022]

Results: The mean age was 52.6 years and Sex-ratio was 0.88. Clinically, the thyroid nodule was hard (5cases) fixed (2cases) associated with adenopathy in 6 cases and recurrent paralysis in 4 cases. Ultrasound showed nodules classified Eutirads 5 (12cases) and Eutirads 4 (5cases). The mean value of calcitonin was 1061 pg/ml. Five patients had distant bone metastasis, pulmonary metastasis in 2 cases and hepatic metastasis in 2 cases. Total thyroidectomy was performed in 15 cases associated with central lymph-nodes dissection in 12 cases and lateral lymph-nodes dissection in 8 cases. A radical lymph-nodes dissection was necessary in 2 cases. A tracheal resection and anastomosis were performed in one patient. For two patients, only a thyroid biopsy was performed. On final histology exam, multifocality was found in 4 cases. The average tumor size was 2.96 cm. Lymph-node involvement was found in 6 cases. Postoperative radiotherapy was performed in 8 cases. After a mean follow-up of 2.4 years, five patients presented a metastatic recurrence. Three patients received targeted therapy.

Conclusion: MTC is a rare neuroendocrine tumor. The increasing knowledge about diagnostic and therapeutic strategies has been leading to better prognosis.