ETA2024 Poster Presentations Diagnosis of thyroid cancer-1 (10 abstracts)
Differences and analogies in thyroid cancer discovered incidentally or by thyroid related screening: a multicenter study
Rosaria Ruggeri 1 , Spyridon Chytiris 2 , Camilla Virili 3 , Carlo Cappelli 4 , Marsida Teliti 5 , Flavia MAgri 5 , Laura Croce 6 , Alfredo Campennì 7 & Mario Rotondi 5
1University of Messina, Department of Human Patology Detev, Endocrine Unit, Messina, Italy; 2Unit of Endocrinology and Metabolism, Laboratory for Endocrine Disruptors, Istituti Clinici Scientifici Maugeri Irccs, 27100, Pavia, Italy., Pavia, Italy; 3Sapienza, University of Rome, Department of Medico-Surgical Sciences and Biotechnologies, Medico-Surgical Sciences and Biotechnologies, Latina, Italy; 4Department of Med. & Surg. Sciences, Internal Med. and Endocrin. Unit, University of Br, Brescia, Italy; 5University of Pavia, Ics Maugeri, Pavia, Italy; 6University of Pavia, Department of Internal Medicine and Therapeutics, Italy; 7Dep. of Biomedical and Dental Sciences, and Morfo-Functional Images, Nuclear Medicine Unit, University of Messina, Messina, Italy
Objective: The prevalence of Thyroid-Cancer (TC) has increased worldwide and an association with metabolic and cardio-vascular disorders has been reported. Nevertheless, an increasing percentage of patients are currently diagnosed incidentally through non-thyroid related imaging for other clinical conditions. Our aim was to assess the prevalence of Thyroid-Related (TD) vs Incidental (ID) reason leading to TC diagnosis and to compare the two groups in terms of clinical characteristics, size and severity of TC at presentation and rate of non-thyroid cancers and cardiovascular/metabolic comorbidities.
Methods: We performed a retrospective cohort study in three high-volume hospital-based centers for thyroid diseases (Pavia, Latina and Messina) in Italy. Consecutive patients with TC were enrolled, collecting data on reason leading to TC diagnosis, age, sex, BMI, presence of cardio-metabolic comorbidities and non-thyroid cancer.
Results: Among the 356 enrolled subjects the US diagnosis of TC was prompted by thyroid-related reasons in 283 (79.5%, TD group) and incidental in 73 (20.5%, ID group). The ID group patients were more frequently males, significantly older and with a higher BMI than the TD group ones, they had a higher rate of non-thyroidal cancers and cardiovascular/metabolic comorbidities. No significant differences could be observed in terms of TC histotype, cancer size, extra-thyroidal extension, lymph-node metastases, AJCC Staging or ATA Risk stratification.
Conclusions: Biological features of TC are similar in the TD and ID groups, but patients in the two groups display significant differences as to their clinical features.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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